WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463726
Description: FCW34 is a novel sialyltransferase inhibitor, inhibiting MDA-MB-231 cell migration and vessel development, suppressing angiogenic activity in transgenic zebrafish models.
MedKoo Cat#: 463726
Chemical Formula: C40H57N7O11
Exact Mass: 811.4116
Molecular Weight: 811.934
Elemental Analysis: C, 59.17; H, 7.08; N, 12.08; O, 21.68
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Synonym: FCW34; FCW 34; FCW-34;
IUPAC/Chemical Name: (S)-4-(((3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-5-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-5-oxopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid
InChi Key: FOFWEYIPXRVWQC-XTRZVKHSSA-N
InChi Code: InChI=1S/C40H57N7O11/c1-24(4-11-35(50)56-21-20-55-19-18-54-17-16-42-46-41)28-7-8-29-27-6-5-25-22-26(12-14-39(25,2)30(27)13-15-40(28,29)3)57-38(51)32(23-34(48)49)43-31-9-10-33(47(52)53)37-36(31)44-58-45-37/h9-10,24-30,32,43H,4-8,11-23H2,1-3H3,(H,48,49)/t24-,25-,26-,27+,28-,29+,30+,32+,39+,40-/m1/s1
SMILES Code: O=C(O)C[C@H](NC1=CC=C([N+]([O-])=O)C2=NON=C21)C(O[C@@H]3CC[C@]4(C)[C@@]5([H])CC[C@]6(C)[C@@H]([C@@H](CCC(OCCOCCOCCN=[N+]=[N-])=O)C)CC[C@@]6([H])[C@]5([H])CC[C@]4([H])C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 811.934 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Fu CW, Tsai HE, Chen WS, Chang TT, Chen CL, Hsiao PW, Li WS. Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis. J Med Chem. 2020 Dec 28. doi: 10.1021/acs.jmedchem.0c01477. Epub ahead of print. PMID: 33371679.