WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463719
CAS#: 1400876-94-9
Description: JAK-IN-3 is a novel potent JAK1/3 inhibitor, targeting JAK3 and JAK1 with IC50 at 3nM and 5nM, respectively.
MedKoo Cat#: 463719
Name: JAK-IN-3
CAS#: 1400876-94-9
Chemical Formula: C18H20N4O3
Exact Mass: 340.1535
Molecular Weight: 340.383
Elemental Analysis: C, 63.52; H, 5.92; N, 16.46; O, 14.10
This product is not in stock, which may be available by custom synthesis.
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Synonym: JAK-IN-3; JAKIN-3; JAK IN-3; JAK-IN 3; JAK-IN3; JAKIN3; JAK IN 3; JAK1/3-IN-22;
IUPAC/Chemical Name: 4-(((2R,3S)-1,3-dihydroxybutan-2-yl)amino)-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide
InChi Key: PRWQQLFMBINSAW-XHDPSFHLSA-N
InChi Code: InChI=1S/C18H20N4O3/c1-11(24)15(10-23)21-17-14(18(19)25)8-20-22-9-13(7-16(17)22)12-5-3-2-4-6-12/h2-9,11,15,21,23-24H,10H2,1H3,(H2,19,25)/t11-,15+/m0/s1
SMILES Code: O=C(C1=C(N[C@@H]([C@@H](O)C)CO)C2=CC(C3=CC=CC=C3)=CN2N=C1)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 340.383 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
