WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463709
CAS#: 384859-58-9
Description: BCH001 is a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.
MedKoo Cat#: 463709
Name: BCH001
CAS#: 384859-58-9
Chemical Formula: C20H15F3N2O5
Exact Mass: 420.0933
Molecular Weight: 420.3442
Elemental Analysis: C, 57.15; H, 3.60; F, 13.56; N, 6.66; O, 19.03
BCH001 is in stock.
Synonym: BCH001; BCH 001; BCH-001;
IUPAC/Chemical Name: 2-((3-(ethoxycarbonyl)-6-(trifluoromethoxy)quinolin-4-yl)amino)benzoic acid
InChi Key: FWJMVZAVAUGMDX-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H15F3N2O5/c1-2-29-19(28)14-10-24-15-8-7-11(30-20(21,22)23)9-13(15)17(14)25-16-6-4-3-5-12(16)18(26)27/h3-10H,2H2,1H3,(H,24,25)(H,26,27)
SMILES Code: FC(F)(F)OC1=CC=C2C(C(NC3=CC=CC=C3C(O)=O)=C(C(OCC)=O)C=N2)=C1
The following data is based on the product molecular weight 420.3442 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Nagpal N, Wang J, Zeng J, Lo E, Moon DH, Luk K, Braun RO, Burroughs LM, Keel SB, Reilly C, Lindsley RC, Wolfe SA, Tai AK, Cahan P, Bauer DE, Fong YW, Agarwal S. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells. Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8. doi: 10.1016/j.stem.2020.03.016. Epub 2020 Apr 21. PMID: 32320679; PMCID: PMC7275922.