VH 032 amide-alkylC3-amine
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MedKoo CAT#: 463679

CAS#: 2564467-25-8

Description: VH 032 amide-alkylC3-amine is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development. It incorporates an E3 ligase ligand plus an alkyl C3 linker and terminal amine ready for conjugation to a target protein ligand. It is part of a range of functionalized tool molecules for PROTAC R&D.


Chemical Structure

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VH 032 amide-alkylC3-amine
CAS# 2564467-25-8

Theoretical Analysis

MedKoo Cat#: 463679
Name: VH 032 amide-alkylC3-amine
CAS#: 2564467-25-8
Chemical Formula: C26H39Cl2N5O4S
Exact Mass: 587.21
Molecular Weight: 588.589
Elemental Analysis: C, 53.06; H, 6.68; Cl, 12.05; N, 11.90; O, 10.87; S, 5.45

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
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Synonym: VH 032 amide-alkylC3-amine; VH032 amide-alkylC3-amine; VH-032 amide-alkylC3-amine;

IUPAC/Chemical Name: (2S,4R)-1-((S)-2-(4-aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

InChi Key: WMBHSWGXRVCMQP-YEMZLKFISA-N

InChi Code: InChI=1S/C26H37N5O4S.2ClH/c1-16-22(36-15-29-16)18-9-7-17(8-10-18)13-28-24(34)20-12-19(32)14-31(20)25(35)23(26(2,3)4)30-21(33)6-5-11-27;;/h7-10,15,19-20,23,32H,5-6,11-14,27H2,1-4H3,(H,28,34)(H,30,33);2*1H/t19-,20+,23-;;/m1../s1

SMILES Code: CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCN)=O)C(C)(C)C)=O)=O)C=C2.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 588.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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