Zaldaride (free base)

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MedKoo CAT#: 412755

CAS#: 109826-26-8 (free base)

Description: Zaldaride (free base) is a calmodulin antagonist.


Chemical Structure

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Zaldaride (free base)
CAS# 109826-26-8 (free base)

Theoretical Analysis

MedKoo Cat#: 412755
Name: Zaldaride (free base)
CAS#: 109826-26-8 (free base)
Chemical Formula: C26H28N4O2
Exact Mass: 428.2212
Molecular Weight: 428.54
Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 109826-26-8 (free base)   109826-27-9 (maleate)  

Synonym: Zaldaride (free base); CGS9343B; CGS-9343B; CGS 9343B

IUPAC/Chemical Name: (+-)-1-(1-((4-Methyl-4H,6H-pyrrolo(1,2-a)(4,1)benzoxazepin-4-yl)methyl)-4-piperidyl)-2-benzimidazolinone

InChi Key: GTJCOJYEIQLGNQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H27N4O2/c1-23(15-24-19-7-3-2-6-17(19)14-29-23)16-26-12-10-18(11-13-26)27-21-9-5-4-8-20(21)25-22(27)28/h2-9,18H,10-16H2,1H3,(H,25,28)

SMILES Code: O=C1NC2=CC=CC=C2N1C3CCN(CC4(C)C[N]C5=CC=CC=C5CO4)CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 428.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Powlin SS, Keng PC, Miller RK. Toxicity of cadmium in human trophoblast cells (JAr choriocarcinoma): role of calmodulin and the calmodulin inhibitor, zaldaride maleate. Toxicol Appl Pharmacol. 1997 Jun;144(2):225-34. doi: 10.1006/taap.1997.8135. PMID: 9194406.

2: Okhuysen PC, DuPont HL, Ericsson CD, Marani S, Martinez-Sandoval FG, Olesen MA, Ravelli GP. Zaldaride maleate (a new calmodulin antagonist) versus loperamide in the treatment of traveler's diarrhea: randomized, placebo- controlled trial. Clin Infect Dis. 1995 Aug;21(2):341-4. doi: 10.1093/clinids/21.2.341. PMID: 8562742.

3: Silberschmidt G, Schick MT, Steffen R, Kilpatrick ME, Murphy JR, Oyofo BA, el-Etr S, Gyurech D, Mourad AS, Mathewson JT, et al. Treatment of travellers' diarrhoea: zaldaride compared with loperamide and placebo. Eur J Gastroenterol Hepatol. 1995 Sep;7(9):871-5. PMID: 8574720.

4: Aikawa N, Karasawa A, Ohmori K. Effect of zaldaride maleate, an antidiarrheal compound, on 16,16-dimethyl prostaglandin E2-induced intestinal ion secretion in rats. Jpn J Pharmacol. 2000 Jul;83(3):269-72. doi: 10.1254/jjp.83.269. PMID: 10952078.

5: Aikawa N, Ohmori K. Effect of zaldaride maleate, an antidiarrheal compound, on fecal pellet output induced by hyperpropulsion in gastrointestine of rats. Jpn J Pharmacol. 2000 Apr;82(4):350-2. doi: 10.1254/jjp.82.350. PMID: 10875756.

6: Aikawa N, Horikoshi K, Maeda H, Kobayashi H, Ohmori K. Antidiarrheal effects of zaldaride maleate after oral, intravenous and subcutaneous administration to rats. Jpn J Pharmacol. 1999 Dec;81(4):397-400. doi: 10.1254/jjp.81.397. PMID: 10669047.

7: Aikawa N, Horikoshi K, Maeda H, Kobayashi H, Ohmori K. Comparison of the antidiarrheal effects of zaldaride maleate and its optical isomers in rats. Biol Pharm Bull. 2000 Apr;23(4):402-5. doi: 10.1248/bpb.23.402. PMID: 10784416.

8: Ericsson CD. Travellers' diarrhoea. Int J Antimicrob Agents. 2003 Feb;21(2):116-24. doi: 10.1016/s0924-8579(02)00282-0. PMID: 12615374.

9: Aikawa N, Kishibayashi N, Karasawa A, Ohmori K. The effect of zaldaride maleate, an antidiarrheal compound, on acetylcholine-induced intestinal electrolyte secretion. Biol Pharm Bull. 2000 Nov;23(11):1377-8. doi: 10.1248/bpb.23.1377. PMID: 11085370.

10: Aikawa N, Karasawa A. Effects of KW-5617 (zaldaride maleate), a potent and selective calmodulin inhibitor, on secretory diarrhea and on gastrointestinal propulsion in rats. Jpn J Pharmacol. 1998 Feb;76(2):199-206. doi: 10.1254/jjp.76.199. PMID: 9541283.