M22 NEDD8 inhibitor
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555899

CAS#: 864420-54-2

Description: M22 NEDD8 inhibitor is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor. M22 is reversible for NAE, inhibits multiple cancer cell lines with GI50 values in the low micromolar range, and induces apoptosis in A549 cells. Furthermore, it produces tumor inhibition in AGS xenografts in nude mice and low acute toxicity in a zebrafish model. M22, a novel NAE inhibitor, represents a promising lead structure for the development of new antitumor agents.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1250 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 2950 2 Weeks
1g USD 3850 2 Weeks
2g USD 6450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-22. Prices are subject to change without notice.

M22 NEDD8 inhibitor is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555899
Name: M22 NEDD8 inhibitor
CAS#: 864420-54-2
Chemical Formula: C20H24Cl2N2
Exact Mass: 362.1317
Molecular Weight: 363.326
Elemental Analysis: C, 66.12; H, 6.66; Cl, 19.51; N, 7.71


Synonym: M22 NEDD8 inhibitor; M22; M-22; M 22;

IUPAC/Chemical Name: 1-benzyl-N-(2,4-dichlorophenethyl)piperidin-4-amine

InChi Key: WMEXQHGRMWPOEF-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24Cl2N2/c21-18-7-6-17(20(22)14-18)8-11-23-19-9-12-24(13-10-19)15-16-4-2-1-3-5-16/h1-7,14,19,23H,8-13,15H2

SMILES Code: ClC1=CC=C(C(Cl)=C1)CCNC2CCN(CC3=CC=CC=C3)CC2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ni S, Chen X, Yu Q, Xu Y, Hu Z, Zhang J, Zhang W, Li B, Yang X, Mao F, Huang J, Sun Y, Li J, Jia L. Discovery of candesartan cilexetic as a novel neddylation inhibitor for suppressing tumor growth. Eur J Med Chem. 2020 Jan 1;185:111848. doi: 10.1016/j.ejmech.2019.111848. Epub 2019 Nov 4. PMID: 31732254.

2: Lu P, Liu X, Yuan X, He M, Wang Y, Zhang Q, Ouyang PK. Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure- Based Virtual Screening. ACS Chem Biol. 2016 Jul 15;11(7):1901-7. doi: 10.1021/acschembio.6b00159. Epub 2016 May 6. PMID: 27135934.