WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463671
CAS#: 491-36-1
Description: 4-HQN is a potent PARP-1 inhibitor and heterocyclic building block. It has been used in the synthesis of compounds with antimalarial or antimicrobial activities in vitro.
MedKoo Cat#: 463671
Name: 4-HQN
CAS#: 491-36-1
Chemical Formula: C8H6N2O
Exact Mass: 146.048
Molecular Weight: 146.149
Elemental Analysis: C, 65.75; H, 4.14; N, 19.17; O, 10.95
Synonym: 4-HQN; 4HQN; 4 HQN; 4-Hydroxyquinazoline; 4 Hydroxyquinazoline;
IUPAC/Chemical Name: quinazolin-4(1H)-one
InChi Key: QMNUDYFKZYBWQX-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
SMILES Code: O=C1N=CNC2=C1C=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 146.149 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Veres B, Radnai B, Gallyas F Jr, Varbiro G, Berente Z, Osz E, Sumegi B. Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther. 2004 Jul;310(1):247-55. doi: 10.1124/jpet.104.065151. Epub 2004 Mar 3. PMID: 14999056.
