WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463671

CAS#: 491-36-1

Description: 4-HQN is a potent PARP-1 inhibitor and heterocyclic building block. It has been used in the synthesis of compounds with antimalarial or antimicrobial activities in vitro.

Chemical Structure

CAS# 491-36-1

Theoretical Analysis

MedKoo Cat#: 463671
Name: 4-HQN
CAS#: 491-36-1
Chemical Formula: C8H6N2O
Exact Mass: 146.048
Molecular Weight: 146.149
Elemental Analysis: C, 65.75; H, 4.14; N, 19.17; O, 10.95

Price and Availability

Size Price Availability Quantity
25.0g USD 450.0 2 Weeks
50.0g USD 950.0 2 Weeks
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Synonym: 4-HQN; 4HQN; 4 HQN; 4-Hydroxyquinazoline; 4 Hydroxyquinazoline;

IUPAC/Chemical Name: quinazolin-4(1H)-one


InChi Code: InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 146.149 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Veres B, Radnai B, Gallyas F Jr, Varbiro G, Berente Z, Osz E, Sumegi B. Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther. 2004 Jul;310(1):247-55. doi: 10.1124/jpet.104.065151. Epub 2004 Mar 3. PMID: 14999056.


25.0g / USD 450.0