WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412727
CAS#: 787582-98-3
Description: VPC 23153 is a sphingosine 1-phosphate 4 receptor agonist. This hygroscopic phospholipid causes contraction of pulmonary artries in rats.
MedKoo Cat#: 412727
Name: VPC 23153
CAS#: 787582-98-3
Chemical Formula: C17H28N3O4P
Exact Mass: 369.1817
Molecular Weight: 369.4
Elemental Analysis: C, 55.28; H, 7.64; N, 11.38; O, 17.32; P, 8.38
Synonym: VPC 23153; (R)-phosphoric acid mono-[2-amino-2-(6-octyl-1H-benzoimiazol-2-yl)-ethyl] ester (ammonium salt)
IUPAC/Chemical Name: (R)-2-ammonio-2-(5-octyl-1H-benzo[d]imidazol-2-yl)ethyl hydrogen phosphate
InChi Key: FZEKCWYSFVMPDZ-AWEZNQCLSA-N
InChi Code: InChI=1S/C17H28N3O4P/c1-2-3-4-5-6-7-8-13-9-10-15-16(11-13)20-17(19-15)14(18)12-24-25(21,22)23/h9-11,14H,2-8,12,18H2,1H3,(H,19,20)(H2,21,22,23)/t14-/m0/s1
SMILES Code: CCCCCCCCC1=CC=C2C(N=C([C@H](COP(O)([O-])=O)[NH3+])N2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 369.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Ota H, Beutz MA, Ito M, Abe K, Oka M, McMurtry IF. S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs. Pulm Circ. 2011 Jul-Sep;1(3):399-404. doi: 10.4103/2045-8932.87309. PMID: 22140630; PMCID: PMC3224432.
