WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463587

CAS#: 221452-76-2

Description: EF-7412 is a ligand that is characterized as an antagonist in vivo in pre- and postsynaptic 5-HT(1A)R sites.

Chemical Structure

CAS# 221452-76-2

Theoretical Analysis

MedKoo Cat#: 463587
Name: EF-7412
CAS#: 221452-76-2
Chemical Formula: C22H33N5O4S
Exact Mass: 463.2253
Molecular Weight: 463.597
Elemental Analysis: C, 57.00; H, 7.18; N, 15.11; O, 13.80; S, 6.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: EF-7412; EF7412; EF 7412;

IUPAC/Chemical Name: N-(3-(4-(4-(1,3-dioxotetrahydro-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)butyl)piperazin-1-yl)phenyl)ethanesulfonamide


InChi Code: InChI=1S/C22H33N5O4S/c1-2-32(30,31)23-18-7-5-8-19(17-18)25-15-13-24(14-16-25)10-3-4-11-27-21(28)20-9-6-12-26(20)22(27)29/h5,7-8,17,20,23H,2-4,6,9-16H2,1H3

SMILES Code: CCS(=O)(Nc1cc(N2CCN(CC2)CCCCN3C(C4CCCN4C3=O)=O)ccc1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 463.597 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: López-Rodríguez ML, Morcillo MJ, Fernández E, Rosado ML, Pardo L, Schaper K. Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition. J Med Chem. 2001 Jan 18;44(2):198-207. doi: 10.1021/jm000930t. PMID: 11170629.

2: López-Rodríguez ML, Morcillo MJ, Fernández E, Porras E, Orensanz L, Beneytez ME, Manzanares J, Fuentes JA. Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties. J Med Chem. 2001 Jan 18;44(2):186-97. doi: 10.1021/jm000929u. PMID: 11170628.

3: López-Rodríguez ML, Morcillo MJ, Fernández E, Rosado ML, Orensanz L, Beneytez ME, Manzanares J, Fuentes JA, Schaper KJ. Design and synthesis of 2-[4-[4-(m-(ethylsulfonamido)-phenyl) piperazin-1-yl]butyl]-1,3-dioxoperhydropyrrolo[1,2-c]imidazole (EF-7412) using neural networks. A selective derivative with mixed 5-HT1A/D2 antagonist properties. Bioorg Med Chem Lett. 1999 Jun 21;9(12):1679-82. doi: 10.1016/s0960-894x(99)00254-1. PMID: 10397500.