15-beta PGF2α

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MedKoo CAT#: 412673

CAS#: 37658-84-7

Description: 15-beta PGF2α is a biochemical

Chemical Structure

15-beta PGF2α
CAS# 37658-84-7

Theoretical Analysis

MedKoo Cat#: 412673
Name: 15-beta PGF2α
CAS#: 37658-84-7
Chemical Formula: C20H34O5
Exact Mass: 354.2406
Molecular Weight: 354.49
Elemental Analysis: C, 67.77; H, 9.67; O, 22.57

Price and Availability

Size Price Availability Quantity
1.0mg USD 319.0 2 Weeks
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Synonym: 15-beta PGF2α; Prostaglandin F2α (15 beta epimer)

IUPAC/Chemical Name: (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid


InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17-,18+,19-/m1/s1

SMILES Code: O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@H](O)CCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 354.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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3: Liston TE, Roberts LJ 2nd. Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta- prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6030-4. doi: 10.1073/pnas.82.18.6030. PMID: 3862115; PMCID: PMC390693.

4: Beasley CR, Robinson C, Featherstone RL, Varley JG, Hardy CC, Church MK, Holgate ST. 9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. J Clin Invest. 1987 Mar;79(3):978-83. doi: 10.1172/JCI112909. PMID: 3469218; PMCID: PMC424254.

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6: Giles H, Bolofo ML, Lydford SJ, Martin GR. A comparative study of the prostanoid receptor profile of 9 alpha 11 beta-prostaglandin F2 and prostaglandin D2. Br J Pharmacol. 1991 Oct;104(2):541-9. doi: 10.1111/j.1476-5381.1991.tb12465.x. PMID: 1665742; PMCID: PMC1908534.

7: Misso NL, Aggarwal S, Phelps S, Beard R, Thompson PJ. Urinary leukotriene E4 and 9 alpha, 11 beta-prostaglandin F concentrations in mild, moderate and severe asthma, and in healthy subjects. Clin Exp Allergy. 2004 Apr;34(4):624-31. doi: 10.1111/j.1365-2222.2004.1912.x. PMID: 15080817.

8: Beasley R, Varley J, Robinson C, Holgate ST. Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma. Am Rev Respir Dis. 1987 Nov;136(5):1140-4. doi: 10.1164/ajrccm/136.5.1140. PMID: 2960256.

9: O'Sullivan S, Dahlén B, Dahlén SE, Kumlin M. Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction. J Allergy Clin Immunol. 1996 Aug;98(2):421-32. doi: 10.1016/s0091-6749(96)70167-7. PMID: 8757220.

10: Ohara H, Nakayama T, Deyashiki Y, Hara A, Miyabe Y, Tsukada F. Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha- hydroxysteroid/dihydrodiol dehydrogenase isozyme. Biochim Biophys Acta. 1994 Nov 17;1215(1-2):59-65. doi: 10.1016/0005-2760(94)90091-4. PMID: 7948008.