Dantrolene sodium hydrate

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MedKoo CAT#: 575280

CAS#: 24868-20-0

Description: Dantrolene sodium hydrate is an inhibitor of calcium release from the sarcoplasmic reticulum. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in cardiomyocytes. Formulations containing Dantrolene have been used in the treatment of malignant hyperthermia.


Chemical Structure

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Dantrolene sodium hydrate
CAS# 24868-20-0

Theoretical Analysis

MedKoo Cat#: 575280
Name: Dantrolene sodium hydrate
CAS#: 24868-20-0
Chemical Formula: C28H32N8Na2O17
Exact Mass: 798.17
Molecular Weight: 798.580
Elemental Analysis: C, 42.11; H, 4.04; N, 14.03; Na, 5.76; O, 34.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Dantamacrin; Dantrium; Dantrix; Dantrolene sodium hemiheptahydrate; Dantrolene sodium hydrate; F-440; F440

IUPAC/Chemical Name: sodium (E)-3-(((5-(4-nitrophenyl)furan-2-yl)methylene)amino)-2,5-dioxoimidazolidin-1-ide heptahydrate

InChi Key: LTWQNYPDAUSXBC-CDJGKPBYSA-L

InChi Code: InChI=1S/2C14H10N4O5.2Na.7H2O/c2*19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;;;;;;;;;/h2*1-7H,8H2,(H,16,19,20);;;7*1H2/q;;2*+1;;;;;;;/p-2/b2*15-7+;;;;;;;;;

SMILES Code: O.O.O.O.O.O.O.[Na+].[Na+].[O-][N+](=O)c1ccc(cc1)c2oc(\C=N\N3CC(=O)[N-]C3=O)cc2.[O-][N+](=O)c4ccc(cc4)c5oc(\C=N\N6CC(=O)[N-]C6=O)cc5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 798.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kobayashi, S., Yano, M., Suetomi, T., et al. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J. Am. Coll. Cardiol. 53(21), 1993-2005 (2009).

2. Oo, Y.W., Gomez-Hurtado, N., Walweel, K., et al. Essential role of calmodulin in RyR inhibition by dantrolene. Mol. Pharmacol. 88(1), 57-63 (2015).

3. Kotsias, B.A., and Muchnik, S. Reversible effect of dantrolene sodium on twitch tension of rat skeletal muscle. Arch. Neurol. 35(4), 234-236 (1978).

4. Nelson, T.E., and Flewellen, E.H. Rationale for dantrolene vs. procainamide for treatment of malignant hyperthermia. Anesthesiology 50(2), 118-122 (1979).