22:0 Trehalose

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412669

CAS#: 66758-35-8

Description: Incorporation of the glycolipid trehalose 6,6'-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets.

Chemical Structure

22:0 Trehalose
CAS# 66758-35-8

Theoretical Analysis

MedKoo Cat#: 412669
Name: 22:0 Trehalose
CAS#: 66758-35-8
Chemical Formula: C56H106O13
Exact Mass: 986.7633
Molecular Weight: 987.45
Elemental Analysis: C, 68.12; H, 10.82; O, 21.06

Price and Availability

Size Price Availability Quantity
5.0mg USD 451.0 2 Weeks
25.0mg USD 1375.0 2 Weeks
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Synonym: 22:0 Trehalose; D-(+)-trehalose 6,6'-dibehenate

IUPAC/Chemical Name: ((2R,2'R,3S,3'S,4S,4'S,5R,5'R,6R,6'R)-oxybis(3,4,5-trihydroxytetrahydro-2H-pyran-6,2-diyl))bis(methylene) didocosanoate


InChi Code: InChI=1S/C56H106O13/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39-41-47(57)65-43-45-49(59)51(61)53(63)55(67-45)69-56-54(64)52(62)50(60)46(68-56)44-66-48(58)42-40-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h45-46,49-56,59-64H,3-44H2,1-2H3/t45-,46-,49-,50-,51+,52+,53-,54-,55-,56-/m1/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 987.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Cejka C, Kubinova S, Cejkova J. Trehalose in ophthalmology. Histol Histopathol. 2019 Jun;34(6):611-618. doi: 10.14670/HH-18-082. Epub 2019 Jan 9. PMID: 30623968.

2: Lee HJ, Yoon YS, Lee SJ. Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction. Cell Death Dis. 2018 Jun 15;9(7):712. doi: 10.1038/s41419-018-0749-9. PMID: 29907758; PMCID: PMC6003909.

3: Zhang Y, DeBosch BJ. Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms. Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):303-310. doi: 10.1097/MCO.0000000000000568. PMID: 31033580.

4: Soper AK, Ricci MA, Bruni F, Rhys NH, McLain SE. Trehalose in Water Revisited. J Phys Chem B. 2018 Jul 26;122(29):7365-7374. doi: 10.1021/acs.jpcb.8b03450. Epub 2018 Jul 17. PMID: 29965765.

5: Jana S , Kulkarni SS . Synthesis of trehalose glycolipids. Org Biomol Chem. 2020 Mar 18;18(11):2013-2037. doi: 10.1039/d0ob00041h. PMID: 32115587.

6: Walmagh M, Zhao R, Desmet T. Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production. Int J Mol Sci. 2015 Jun 15;16(6):13729-45. doi: 10.3390/ijms160613729. PMID: 26084050; PMCID: PMC4490520.

7: Bragg JT, D'Ambrosio HK, Smith TJ, Gorka CA, Khan FA, Rose JT, Rouff AJ, Fu TS, Bisnett BJ, Boyce M, Khetan S, Paulick MG. Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock. Chembiochem. 2017 Sep 19;18(18):1863-1870. doi: 10.1002/cbic.201700302. Epub 2017 Aug 18. PMID: 28722776.

8: Lee J, Ko JH, Mansfield KM, Nauka PC, Bat E, Maynard HD. Glucose-Responsive Trehalose Hydrogel for Insulin Stabilization and Delivery. Macromol Biosci. 2018 May;18(5):e1700372. doi: 10.1002/mabi.201700372. Epub 2018 Apr 17. PMID: 29665232; PMCID: PMC5986559.

9: Eleutherio E, Panek A, De Mesquita JF, Trevisol E, Magalhães R. Revisiting yeast trehalose metabolism. Curr Genet. 2015 Aug;61(3):263-74. doi: 10.1007/s00294-014-0450-1. Epub 2014 Sep 11. PMID: 25209979.

10: Sakhaee N, Sakhaee S, Takallou A, Mobaraki A, Maddah M, Moshrefi R. Hydrodynamic volume of trehalose and its water uptake mechanism. Biophys Chem. 2019 Jun;249:106145. doi: 10.1016/j.bpc.2019.03.002. Epub 2019 Apr 2. PMID: 30959240.