3A-MPLA
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412665

CAS#: 1699735-80-2

Description: Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.


Chemical Structure

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3A-MPLA
CAS# 1699735-80-2

Theoretical Analysis

MedKoo Cat#: 412665
Name: 3A-MPLA
CAS#: 1699735-80-2
Chemical Formula: C54H106N3O17P
Exact Mass: 1,099.73
Molecular Weight: 1,100.420
Elemental Analysis: C, 58.94; H, 9.71; N, 3.82; O, 24.72; P, 2.81

Price and Availability

Size Price Availability Quantity
1mg USD 2580 2 Weeks
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Synonym: 3A-MPLA; Monophosphoryl Tri-acyl Lipid A

IUPAC/Chemical Name: ammonium (2R,3S,4R,5R,6R)-4-hydroxy-2-(hydroxymethyl)-5-((R)-3-(tetradecanoyloxy)tetradecanamido)-6-(((2R,3S,4R,5R,6S)-3,4,6-trihydroxy-5-((R)-3-hydroxytetradecanamido)tetrahydro-2H-pyran-2-yl)methoxy)tetrahydro-2H-pyran-3-yl hydrogen phosphate

InChi Key: WBMOMCHVNLUEBA-MWYCKLIASA-N

InChi Code: InChI=1S/C54H103N2O17P.H3N/c1-4-7-10-13-16-19-20-23-26-29-32-35-46(61)70-41(34-31-28-25-22-18-15-12-9-6-3)37-45(60)56-48-51(64)52(73-74(66,67)68)42(38-57)72-54(48)69-39-43-49(62)50(63)47(53(65)71-43)55-44(59)36-40(58)33-30-27-24-21-17-14-11-8-5-2;/h40-43,47-54,57-58,62-65H,4-39H2,1-3H3,(H,55,59)(H,56,60)(H2,66,67,68);1H3/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53+,54-;/m1./s1

SMILES Code: O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1100.420000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Grabarek J, Her GR, Reinhold VN, Hawiger J. Endotoxic lipid A interaction with human platelets. Structure-function analysis of lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide. J Biol Chem. 1990 May 15;265(14):8117-21. PMID: 2335520.