Tiagabine-d6 hydrochloride
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MedKoo CAT#: 463567

CAS#: 1217808-68-8 (hydrochloride)

Description: Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of partial seizures.

Chemical Structure

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Tiagabine-d6 hydrochloride
CAS# 1217808-68-8 (hydrochloride)
Instruction

Theoretical Analysis

MedKoo Cat#: 463567
Name: Tiagabine-d6 hydrochloride
CAS#: 1217808-68-8 (hydrochloride)
Chemical Formula: C20H20D6ClNO2S2
Exact Mass: 417.15
Molecular Weight: 418.040
Elemental Analysis: C, 57.46; H, 7.71; Cl, 8.48; N, 3.35; O, 7.65; S, 15.34

Price and Availability

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1mg USD 450 2 Weeks
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Synonym: Tiagabine-d6 hydrochloride; Tiagabine d6 hydrochloride;

IUPAC/Chemical Name: (R)-1-(4,4-bis(3-(methyl-d3)thiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride

InChi Key: YUKARLAABCGMCN-OUCKJYDLSA-N

InChi Code: InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1/i1D3,2D3;

SMILES Code: OC([C@@H]1CCCN(C1)CC/C=C(C2=C(C=CS2)C([2H])([2H])[2H])/C3=C(C=CS3)C([2H])([2H])[2H])=O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 418.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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