WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463567
CAS#: 1217808-68-8 (hydrochloride)
Description: Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of partial seizures.
MedKoo Cat#: 463567
Name: Tiagabine-d6 hydrochloride
CAS#: 1217808-68-8 (hydrochloride)
Chemical Formula: C20H20D6ClNO2S2
Exact Mass: 417.147
Molecular Weight: 418.0396
Elemental Analysis: C, 57.46; H, 7.71; Cl, 8.48; N, 3.35; O, 7.65; S, 15.34
Synonym: Tiagabine-d6 hydrochloride; Tiagabine d6 hydrochloride;
IUPAC/Chemical Name: (R)-1-(4,4-bis(3-(methyl-d3)thiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
InChi Key: YUKARLAABCGMCN-OUCKJYDLSA-N
InChi Code: InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1/i1D3,2D3;
SMILES Code: OC([C@@H]1CCCN(C1)CC/C=C(C2=C(C=CS2)C([2H])([2H])[2H])/C3=C(C=CS3)C([2H])([2H])[2H])=O.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 418.0396 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
