WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412612
CAS#: 62-59-9
Description: Veratrine is a voltage-gated sodium channel activator
MedKoo Cat#: 412612
Name: Veratrine
CAS#: 62-59-9
Chemical Formula: C32H49NO9
Exact Mass: 591.3407
Molecular Weight: 591.74
Elemental Analysis: C, 64.95; H, 8.35; N, 2.37; O, 24.33
Synonym: Veratrine; Cevadin; Cevadene; NSC 93767
IUPAC/Chemical Name: (3S,4S,4aS,6aS,6bR,8S,8aS,9R,9aS,12S,15aS,15bR,16aR,16bS)-4,6b,8,8a,9,15b-hexahydroxy-9,12,16b-trimethyldocosahydro-2H-4,16a-epoxybenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinolin-3-yl (Z)-2-methylbut-2-enoate
InChi Key: DBUCFOVFALNEOO-HWBIYQLFSA-N
InChi Code: InChI=1S/C32H49NO9/c1-6-18(3)25(35)41-24-11-12-26(4)19-8-9-20-28(37)13-23(34)31(39)21(29(28,38)16-30(20,26)42-32(19,24)40)15-33-14-17(2)7-10-22(33)27(31,5)36/h6,17,19-24,34,36-40H,7-16H2,1-5H3/b18-6-/t17-,19-,20-,21-,22-,23-,24-,26-,27+,28+,29+,30+,31-,32-/m0/s1
SMILES Code: C/C=C(C(O[C@H]1CC[C@]2([C@@H]3CC[C@H]4[C@@]5(C[C@@H]([C@]6([C@H]([C@@]5(C[C@]24O[C@]13O)O)CN7C[C@H](CC[C@H]7[C@]6(O)C)C)O)O)O)C)=O)/C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 591.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Saitoh A, Makino Y, Hashimoto T, Yamada M, Gotoh L, Sugiyama A, Ohashi M, Tsukagoshi M, Oka J, Yamada M. The voltage-gated sodium channel activator veratrine induces anxiogenic-like behaviors in rats. Behav Brain Res. 2015 Oct 1;292:316-22. doi: 10.1016/j.bbr.2015.06.022. Epub 2015 Jun 19. PMID: 26099814.
2: LUTEMBACHER R. [Veratrine]. Arch Mal Coeur Vaiss. 1959 Sep;52:961-6. French. PMID: 14419049.
3: Hiraoka M. [Veratrine, aconitine and excitation enhancement]. Nihon Rinsho. 1979;37(7):2820-5. Japanese. PMID: 93652.
4: Tsai HY, Lin YT, Chen CF, Tsai CH, Chen YF. Effects of veratrine and paeoniflorin on the isolated rat aorta. J Ethnopharmacol. 1999 Sep;66(3):249-55. doi: 10.1016/s0378-8741(98)00236-0. PMID: 10473169.
5: Le Grand B, Marty A, Vieu S, Talmant JM, John GW. Veratrine-induced tetanic contracture of the rat isolated left atrium. Evidence for novel direct protective effects of prazosin and WB4101. Naunyn Schmiedebergs Arch Pharmacol. 1993 Aug;348(2):184-90. doi: 10.1007/BF00164797. PMID: 7901775.
6: JACOBS WA, SATO Y. The veratrine alkaloids; a further study of the structure of veratramine and jervine. J Biol Chem. 1949 Nov;181(1):55-65. PMID: 15390391.
7: Chen YF, Lin YT, Tan TW, Tsai HY. Effects of veratrine and paeoniflorin on isolated mouse vas deferens. Phytomedicine. 2002 May;9(4):296-301. doi: 10.1078/0944-7113-00122. PMID: 12120810.
8: Tsai HY, Lin YT, Chen YF, Chen CF. The interactions of paeoniflorin and veratrine on isolated rat atria. J Ethnopharmacol. 1997 Aug;57(3):169-76. doi: 10.1016/s0378-8741(97)00066-4. PMID: 9292409.
9: Villegas J, Sevcik C, Barnola FV, Villegas R. Grayanotoxin, veratrine, and tetrodotoxin-sensitive sodium pathways in the Schwann cell membrane of squid nerve fibers. J Gen Physiol. 1976 Mar;67(3):369-80. doi: 10.1085/jgp.67.3.369. PMID: 1262854; PMCID: PMC2214968.
10: Codagnone FT, Consoni FT, Rodrigues AL, Vital MA, Andreatini R. Veratrine blocks the lamotrigine-induced swimming increase and immobility decrease in the modified forced swimming test. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1307-11. doi: 10.1016/j.pnpbp.2007.05.017. Epub 2007 Jun 7. PMID: 17619070.
