WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463547

CAS#: 38273-00-6

Description: Edikron is a Czechoslovak cytostatic agent.

Chemical Structure

CAS# 38273-00-6

Theoretical Analysis

MedKoo Cat#: 463547
Name: Edikron
CAS#: 38273-00-6
Chemical Formula: C20H20Br2O2
Exact Mass: 449.983
Molecular Weight: 452.186
Elemental Analysis: C, 53.12; H, 4.46; Br, 35.34; O, 7.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Edikron;

IUPAC/Chemical Name: (E)-2,3-dibromo-4,4-bis(4-ethylphenyl)but-2-enoic acid


InChi Code: InChI=1S/C20H20Br2O2/c1-3-13-5-9-15(10-6-13)17(18(21)19(22)20(23)24)16-11-7-14(4-2)8-12-16/h5-12,17H,3-4H2,1-2H3,(H,23,24)/b19-18+

SMILES Code: CCc1ccc(C(c2ccc(CC)cc2)/C(Br)=C(C(O)=O)\Br)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 452.186 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Drsata J, Hais IM, Malon P. Interaction of Z-4,4-bis(4-ethylphenyl)-2,3-dibromo-2-butenoic acid with aminotransferases: changes in absorption and circular dichroism spectra. Drug Metabol Drug Interact. 1991;9(3-4):255-68. doi: 10.1515/dmdi.1991.9.3-4.255. PMID: 1824079.

2: Klimes J, Zahradnícek M. HPLC-Bestimmung des Cancerostaticums Edikron im Ratten-plasma [HPLC determination of the carcinostatic Edikron in rat plasma]. Pharmazie. 1987 Oct;42(10):699. German. PMID: 3438326.

3: Klíma J, Grafnetterová J, Jiricka Z, Masek K. Study of the effect of Edikron on the immune system. Physiol Bohemoslov. 1985;34(2):183-7. PMID: 3161109.

4: Francová V, Smolík S, Schlehrová M, Krepelka J, Ausková M, Franc Z, Rezábek K, Semonský M. Biochemistry of drugs. XXIV. Substances with antineoplastic effect. LXII. Pharmacokinetics of gamma,gamma-bis-4-ethylphenyl-alpha,beta- dibromoisocrotonic acid-3H (Edikron-3H) in experimental animals. Neoplasma. 1978;25(4):395-404. PMID: 692801.

5: Sýkora I, Gandalovicová D. Dominant-lethal assay of selected cytostatics. Neoplasma. 1978;25(5):523-33. PMID: 581697.

6: Helia O, Jindra A, Semonský M, Slavíková M. Vliv kyseliny gamma, gamma-bis-p- ethylfenyl-alpha,beta-di-bromisokrotonové (Edikronu) na nĕkteré enzymy in vitro [Effect of gamma, gamma-bis-p-ethylpenyl-alpha,beta-di-bromisocrotonic acid (Edikron) on various enzymes in vitro]. Cesk Farm. 1973 Nov;22(9):404-5. Czech. PMID: 4775961.