JHU 37152
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463510

CAS#: 2369979-67-7

Description: JHU 37152 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. It is brain penetrant in mice, rats and non-human primates.


Chemical Structure

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JHU 37152
CAS# 2369979-67-7

Theoretical Analysis

MedKoo Cat#: 463510
Name: JHU 37152
CAS#: 2369979-67-7
Chemical Formula: C19H20ClFN4
Exact Mass: 358.1361
Molecular Weight: 358.8454
Elemental Analysis: C, 63.60; H, 5.62; Cl, 9.88; F, 5.29; N, 15.61

Price and Availability

Size Price Availability Quantity
10.0mg USD 360.0 2 Weeks
50.0mg USD 1050.0 2 Weeks
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Synonym: JHU 37152; JHU-37152; JHU37152;

IUPAC/Chemical Name: 8-chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine

InChi Key: NZMZJNNWMSYDNX-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-18-14(21)4-3-5-16(18)22-15-7-6-13(20)12-17(15)23-19/h3-7,12,22H,2,8-11H2,1H3

SMILES Code: CCN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC(F)=C24

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 358.8454 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z. PMID: 31604917; PMCID: PMC6788984.