WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463510
Description: JHU 37152 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. It is brain penetrant in mice, rats and non-human primates.
MedKoo Cat#: 463510
Name: JHU 37152
Chemical Formula: C19H20ClFN4
Exact Mass: 358.1361
Molecular Weight: 358.8454
Elemental Analysis: C, 63.60; H, 5.62; Cl, 9.88; F, 5.29; N, 15.61
Synonym: JHU 37152; JHU-37152; JHU37152;
IUPAC/Chemical Name: 8-chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine
InChi Key: NZMZJNNWMSYDNX-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-18-14(21)4-3-5-16(18)22-15-7-6-13(20)12-17(15)23-19/h3-7,12,22H,2,8-11H2,1H3
SMILES Code: CCN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC(F)=C24
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 358.8454 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bonaventura J, Eldridge MAG, Hu F, Gomez JL, Sanchez-Soto M, Abramyan AM, Lam S, Boehm MA, Ruiz C, Farrell MR, Moreno A, Galal Faress IM, Andersen N, Lin JY, Moaddel R, Morris PJ, Shi L, Sibley DR, Mahler SV, Nabavi S, Pomper MG, Bonci A, Horti AG, Richmond BJ, Michaelides M. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 Oct 11;10(1):4627. doi: 10.1038/s41467-019-12236-z. PMID: 31604917; PMCID: PMC6788984.