KBJK557

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463426

CAS#: 2660138-04-3

Description: KBJK557 is a novel Plk1 PBD inhibitor, showing a remarkable in vitro anticancer effect by inducing Plk1 delocalization, mitotic arrest, and apoptosis in HeLa cells. KBJK557 showed a remarkable in vitro anticancer effect by inducing Plk1 delocalization, mitotic arrest, and apoptosis in HeLa cells. Further, in vivo optical imaging analysis and antitumorigenic activities in mouse xenograft models demonstrate that KBJK557 preferentially accumulates in cancer cells and selectively inhibits cancer cell proliferation.


Chemical Structure

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KBJK557
CAS# 2660138-04-3

Theoretical Analysis

MedKoo Cat#: 463426
Name: KBJK557
CAS#: 2660138-04-3
Chemical Formula: C24H22N6O4
Exact Mass: 458.17
Molecular Weight: 458.478
Elemental Analysis: C, 62.87; H, 4.84; N, 18.33; O, 13.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: KBJK557; KBJK 557; KBJK-557;

IUPAC/Chemical Name: 4-(methylamino)-N-(2-(3-phenyl-4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)-1H-pyrazol-1-yl)ethyl)benzamide

InChi Key: WEWSXPJRYDQPAO-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H22N6O4/c1-25-18-9-7-16(8-10-18)21(31)26-11-12-30-14-17(20(29-30)15-5-3-2-4-6-15)13-19-22(32)27-24(34)28-23(19)33/h2-10,13-14,25H,11-12H2,1H3,(H,26,31)(H2,27,28,32,33,34)

SMILES Code: O=C(NCCN1N=C(C2=CC=CC=C2)C(/C=C(C(N3)=O)/C(NC3=O)=O)=C1)C4=CC=C(NC)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 458.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gunasekaran P, Yim MS, Ahn M, Soung NK, Park JE, Kim J, Bang G, Shin SC, Choi J, Kim M, Kim HN, Lee YH, Chung YH, Lee K, EunKyeong Kim E, Jeon YH, Kim MJ, Lee KR, Kim BY, Lee KS, Ryu EK, Bang JK. Development of a Polo-like Kinase-1 Polo- Box Domain Inhibitor as a Tumor Growth Suppressor in Mice Models. J Med Chem. 2020 Nov 3. doi: 10.1021/acs.jmedchem.0c01451. Epub ahead of print. PMID: 33142063.