WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463424
Description: K114 is an inhibitor of ER stress-induced splicing of XBP1 mRNA as well as reporter luciferase expression in HCT116 cells derived from human colorectal carcinoma, and inhibiting ribonuclease activity of human IRE1α in vitro.
MedKoo Cat#: 463424
Chemical Formula: C22H17BrO2
Exact Mass: 392.0412
Molecular Weight: 393.28
Elemental Analysis: C, 67.19; H, 4.36; Br, 20.32; O, 8.14
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: K114; K 114; K-114;
IUPAC/Chemical Name: 4,4'-((1E,1'E)-(2-bromo-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
InChi Key: OXPHQQMZTXMEGO-RJTULKDBSA-N
InChi Code: InChI=1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+
SMILES Code: OC(C=C1)=CC=C1/C=C/C2=CC=C(/C=C/C3=CC=C(O)C=C3)C(Br)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 393.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Jin B, Ishikawa T, Taniguchi M, Ninagawa S, Okada T, Kagaya S, Mori K. Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish. Cell Struct Funct. 2020 Feb 7;45(1):23-31. doi: 10.1247/csf.19032. Epub 2019 Dec 26. PMID: 31875595.
2: Liu J, Ye YH, Shao YH, Tu ZC. Observation of the structural changes of α-lactalbumin induced by ultrasonic prior to glycated modification. J Food Biochem. 2019 Nov;43(11):e13017. doi: 10.1111/jfbc.13017. Epub 2019 Sep 8. PMID: 31495937.
3: Maslovskaja J, Saare M, Liiv I, Rebane A, Peterson P. Extended HSR/CARD domain mediates AIRE binding to DNA. Biochem Biophys Res Commun. 2015 Dec 25;468(4):913-20. doi: 10.1016/j.bbrc.2015.11.056. Epub 2015 Nov 27. PMID: 26607109.