WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463424

CAS#: 872201-12-2

Description: K114 is an inhibitor of ER stress-induced splicing of XBP1 mRNA as well as reporter luciferase expression in HCT116 cells derived from human colorectal carcinoma, and inhibiting ribonuclease activity of human IRE1α in vitro.

Chemical Structure

CAS# 872201-12-2

Theoretical Analysis

MedKoo Cat#: 463424
Name: K114
CAS#: 872201-12-2
Chemical Formula: C22H17BrO2
Exact Mass: 392.0412
Molecular Weight: 393.28
Elemental Analysis: C, 67.19; H, 4.36; Br, 20.32; O, 8.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: K114; K 114; K-114;

IUPAC/Chemical Name: 4,4'-((1E,1'E)-(2-bromo-1,4-phenylene)bis(ethene-2,1-diyl))diphenol


InChi Code: InChI=1S/C22H17BrO2/c23-22-15-18(2-1-16-5-11-20(24)12-6-16)4-10-19(22)9-3-17-7-13-21(25)14-8-17/h1-15,24-25H/b2-1+,9-3+

SMILES Code: OC(C=C1)=CC=C1/C=C/C2=CC=C(/C=C/C3=CC=C(O)C=C3)C(Br)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 393.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jin B, Ishikawa T, Taniguchi M, Ninagawa S, Okada T, Kagaya S, Mori K. Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish. Cell Struct Funct. 2020 Feb 7;45(1):23-31. doi: 10.1247/csf.19032. Epub 2019 Dec 26. PMID: 31875595.

2: Liu J, Ye YH, Shao YH, Tu ZC. Observation of the structural changes of α-lactalbumin induced by ultrasonic prior to glycated modification. J Food Biochem. 2019 Nov;43(11):e13017. doi: 10.1111/jfbc.13017. Epub 2019 Sep 8. PMID: 31495937.

3: Maslovskaja J, Saare M, Liiv I, Rebane A, Peterson P. Extended HSR/CARD domain mediates AIRE binding to DNA. Biochem Biophys Res Commun. 2015 Dec 25;468(4):913-20. doi: 10.1016/j.bbrc.2015.11.056. Epub 2015 Nov 27. PMID: 26607109.