E197

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463401

CAS#: unknown

Description: E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and osteoblast numbers and hence did not impair bone formation. E197 could represent a lead molecule to develop new antiosteoporotic drugs targeting the mechanism of osteoclast adhesion onto the bone.


Chemical Structure

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E197
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 463401
Name: E197
CAS#: unknown
Chemical Formula: C19H21ClN2O3S
Exact Mass: 392.0961
Molecular Weight: 392.898
Elemental Analysis: C, 58.08; H, 5.39; Cl, 9.02; N, 7.13; O, 12.22; S, 8.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: E197; E 197; E-197;

IUPAC/Chemical Name: (4S,5R)-7-(4-chlorobenzyl)-4-hydroxy-2-phenyl-1-thia-2,7-diazaspiro[4.4]nonane 1,1-dioxide

InChi Key: KNPZNXSUFBUIGL-RBUKOAKNSA-N

InChi Code: InChI=1S/C19H21ClN2O3S/c20-16-8-6-15(7-9-16)12-21-11-10-19(14-21)18(23)13-22(26(19,24)25)17-4-2-1-3-5-17/h1-9,18,23H,10-14H2/t18-,19+/m0/s1

SMILES Code: O=S1(N(C2=CC=CC=C2)C[C@H](O)[C@@]13CN(CC4=CC=C(Cl)C=C4)CC3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 392.898 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mounier L, Morel A, Ferrandez Y, Morko J, Vääräniemi J, Gilardone M, Roche D, Cherfils J, Blangy A. Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation. J Med Chem. 2020 Nov 11. doi: 10.1021/acs.jmedchem.0c01201. Epub ahead of print. PMID: 33175535.