Artilide fumarate
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MedKoo CAT#: 575043

CAS#: 133267-20-6 (fumarate)

Description: Artilide, also known as U88943 or U88943E, is a drug used for the treatment of cardiac arrhythmias. Artilide is a class III antiarrhythmic which is structurally-related to ibutilide and d,l-sotalol. Artilide had demonstrated inducibe ventricular arrhythmias prior to treatment. This antiarrhythmic action was associated with significant increases in ventricular refractoriness and monophasic action potential duration. Lower doses of artilide tended to reduce the incidence of spontaneous ventricular arrhythmias but these effects were not significant. These results are consistent with the concept that spontaneous and pacing induced ventricular arrhythmias result from different mechanisms, and that class III anti-arrhythmic agents are more effective in suppressing induced ventricular tachycardia due to reentry than spontaneous arrhythmias which result from nonreentrant mechanisms.

Chemical Structure

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Artilide fumarate
CAS# 133267-20-6 (fumarate)
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 575043
Name: Artilide fumarate
CAS#: 133267-20-6 (fumarate)
Chemical Formula: C42H72N4O10S2
Exact Mass: 486.24
Molecular Weight: 857.176
Elemental Analysis: C, 58.85; H, 8.47; N, 6.54; O, 18.66; S, 7.48

Price and Availability

Size Price Availability Quantity
10mg USD 550 Ready to ship
25mg USD 950 Ready to ship
50mg USD 1650 Ready to ship
100mg USD 2950 Ready to ship
1mg USD 150 Ready to ship
5mg USD 350 Ready to ship
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Related CAS #: 133267-20-6 (fumarate), 133267-19-3 (free base), 100632-85-7 (racemate),

Synonym: Artilide fumarate; U 88943E; U88943E; U-88943E

IUPAC/Chemical Name: (R)-N-(4-(4-(dibutylamino)-1-hydroxybutyl)phenyl)methanesulfonamide hemifumarate

InChi Key: ZOFVDTOFQPSUIK-OMMCMWGNSA-N

InChi Code: InChI=1S/2C19H34N2O3S.C4H4O4/c2*1-4-6-14-21(15-7-5-2)16-8-9-19(22)17-10-12-18(13-11-17)20-25(3,23)24;5-3(6)1-2-4(7)8/h2*10-13,19-20,22H,4-9,14-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*19-;/m11./s1

SMILES Code: CS(=O)(NC1=CC=C([C@H](O)CCCN(CCCC)CCCC)C=C1)=O.O=C(O)/C=C/C(O)=O.CS(=O)(NC2=CC=C([C@H](O)CCCN(CCCC)CCCC)C=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Artilide, also known as U88943 or U88943E, is a drug used for the treatment of cardiac arrhythmias.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 857.176000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1. Hsu CL, Walters RR. Assay of the enantiomers of ibutilide and artilide using solid-phase extraction, derivatization, and achiral-chiral column-switching high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 May 5;667(1):115-28. doi: 10.1016/0378-4347(95)00005-4. PMID: 7663674.