Echitamidine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463385

CAS#: 38681-90-2

Description: Echitamidine is an indole alkaloid isolated from Alstonia boonei. Its laboratory synthesis has been reported.

Chemical Structure

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Echitamidine
CAS# 38681-90-2
Instruction

Theoretical Analysis

MedKoo Cat#: 463385
Name: Echitamidine
CAS#: 38681-90-2
Chemical Formula: C20H24N2O3
Exact Mass: 340.18
Molecular Weight: 340.423
Elemental Analysis: C, 70.57; H, 7.11; N, 8.23; O, 14.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Echitamidine; Echitamidin;

IUPAC/Chemical Name: methyl (3aS,5S,12S)-12-((S)-1-hydroxyethyl)-1,2,3a,4,5,7-hexahydro-5,3-ethanopyrrolo[2,3-d]carbazole-6-carboxylate

InChi Key: DWLJVOJBWLYMJO-CZGIKHJPSA-N

InChi Code: InChI=1S/C20H24N2O3/c1-11(23)13-10-22-8-7-20-14-5-3-4-6-15(14)21-18(20)17(19(24)25-2)12(13)9-16(20)22/h3-6,11-13,16,21,23H,7-10H2,1-2H3/t11-,12-,13-,16-,20?/m0/s1

SMILES Code: COC(C1=C2Nc3c(C24CCN5C[C@H]([C@@H]1C[C@@H]45)[C@@H](O)C)cccc3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lim JL, Sim KS, Yong KT, Loong BJ, Ting KN, Lim SH, Low YY, Kam TS. Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor-secovallesamine with unusual incorporation of a 3-ethylpyridine moiety. Phytochemistry. 2015 Sep;117:317-324. doi: 10.1016/j.phytochem.2015.06.024. Epub 2015 Jun 27. PMID: 26125941.

2: Teijaro CN, Munagala S, Zhao S, Sirasani G, Kokkonda P, Malofeeva EV, Hopper- Borge E, Andrade RB. Synthesis and biological evaluation of pentacyclic strychnos alkaloids as selective modulators of the ABCC10 (MRP7) efflux pump. J Med Chem. 2014 Dec 26;57(24):10383-90. doi: 10.1021/jm501189p. Epub 2014 Dec 8. PMID: 25419978; PMCID: PMC4281106.

3: Adotey JP, Adukpo GE, Opoku Boahen Y, Armah FA. A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). ISRN Pharmacol. 2012;2012:587160. doi: 10.5402/2012/587160. Epub 2012 Jul 30. PMID: 22900200; PMCID: PMC3413980.

4: Ikewuchi JC. Alteration of plasma biochemical, haematological and ocular oxidative indices of alloxan induced diabetic rats by aqueous extract of Tridax procumbens Linn (Asteraceae). EXCLI J. 2012 Jun 18;11:291-308. PMID: 27418906; PMCID: PMC4941802.

5: Ikewuchi JC, Uwakwe AA, Onyeike EN, Ikewuchi CC. Hepatoprotective effect of an aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) against carbon tetrachloride induced liver injury in rats. EXCLI J. 2011 Dec 8;10:280-289. PMID: 29033709; PMCID: PMC5611619.

6: Salim AA, Garson MJ, Craik DJ. New indole alkaloids from the bark of Alstonia scholaris. J Nat Prod. 2004 Sep;67(9):1591-4. doi: 10.1021/np0498612. PMID: 15387668.

7: Li CM, Zhang XM, Zhou YL, Huang LY, Tao GD. [Studies on the indole alkaloids of Winchia calophylla A. DC]. Yao Xue Xue Bao. 1993;28(7):512-5. Chinese. PMID: 8285052.