WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463359
CAS#: unknown
Description: FAPL-PI3Ki1 is a novel FAP-targeted PI3K inhibitor, suppressing phosphorylation of Akt in IPF fibroblasts.
MedKoo Cat#: 463359
Name: FAPL-PI3Ki1
CAS#: unknown
Chemical Formula: C52H48F4N10O12S3
Exact Mass: 1176.2551
Molecular Weight: 1177.1876
Elemental Analysis: C, 53.06; H, 4.11; F, 6.46; N, 11.90; O, 16.31; S, 8.17
This product is not in stock, which may be available by custom synthesis.
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Synonym: FAPL-PI3Ki1; FAPL PI3Ki1; FAP-targeted PI3Ki; FAP targeted PI3Ki;
IUPAC/Chemical Name: N-(4-(((4-(((S)-1-((S)-2-cyano-4,4-difluoropyrrolidin-1-yl)-1-oxopropan-2-yl)carbamoyl)pyridin-2-yl)methyl)amino)-4-oxobutanoyl)-S-((2-((((5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)quinolin-4-yl)pyridin-2-yl)methoxy)carbonyl)oxy)ethyl)thio)-L-cysteine
InChi Key: DXXIUVWNTLDCDL-QWSSMIDASA-N
InChi Code: InChI=1S/C52H48F4N10O12S3/c1-29(49(70)66-28-52(55,56)21-37(66)22-57)63-47(69)31-11-13-58-36(17-31)25-61-45(67)9-10-46(68)64-43(50(71)72)27-80-79-16-15-77-51(73)78-26-35-6-3-32(23-60-35)38-12-14-59-41-7-4-30(18-39(38)41)33-19-42(48(76-2)62-24-33)65-81(74,75)44-8-5-34(53)20-40(44)54/h3-8,11-14,17-20,23-24,29,37,43,65H,9-10,15-16,21,25-28H2,1-2H3,(H,61,67)(H,63,69)(H,64,68)(H,71,72)/t29-,37-,43-/m0/s1
SMILES Code: O=C(O)[C@H](CSSCCOC(OCC1=NC=C(C2=CC=NC3=CC=C(C4=CC(NS(=O)(C5=CC=C(F)C=C5F)=O)=C(OC)N=C4)C=C23)C=C1)=O)NC(CCC(NCC6=NC=CC(C(N[C@@H](C)C(N7[C@H](C#N)CC(F)(F)C7)=O)=O)=C6)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 1177.1876 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
