WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463341
CAS#: 53-84-9 (free acid)
Description: NAD is a dinucleotide of adenine and nicotinamide. It has coenzyme activity in redox reactions and also acts as a donor of ADP-ribose moieties.
MedKoo Cat#: 463341
Name: NAD free acid
CAS#: 53-84-9 (free acid)
Chemical Formula: C21H27N7O14P2
Exact Mass: 663.1091
Molecular Weight: 663.4295
Elemental Analysis: C, 38.02; H, 4.10; N, 14.78; O, 33.76; P, 9.34
Related CAS #: 53-84-9 (free acid) 20111-18-6 (sodium) 58-68-4 (reduced)
Synonym: Nadide; beta-NAD; beta NAD; Codehydrase I; NAD; NAD+; Enzopride; Nadida; Nadidum; Nicotinamide adenine dinucleotide; NSC 20272; NSC20272; NSC-20272;
IUPAC/Chemical Name: 1-((2R,3R,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium
InChi Key: BAWFJGJZGIEFAR-NNYOXOHSSA-N
InChi Code: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
SMILES Code: NC(c1c[n+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP([O-])(OP(O)(OC[C@H]3O[C@@H](n(cn4)c5c4c(N)ncn5)[C@@H]([C@@H]3O)O)=O)=O)ccc1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 663.4295 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Martín Guerrero SM, Casado P, Hijazi M, Rajeeve V, Plaza J, Abadía-Molina F, Navascués J, Cuadros MA, Cutillas PR, Martín-Oliva D. PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability. Biochem J. 2020 Nov 4:BCJ20200525. doi: 10.1042/BCJ20200525. Epub ahead of print. PMID: 33146386.
