B-4162

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574996

CAS#: 103412-42-6

Description: B-4162 is a bradykinin inhibitor.


Chemical Structure

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B-4162
CAS# 103412-42-6

Theoretical Analysis

MedKoo Cat#: 574996
Name: B-4162
CAS#: 103412-42-6
Chemical Formula: C56H83N19O13S2
Exact Mass: 1293.5859
Molecular Weight: 1294.52
Elemental Analysis: C, 51.96; H, 6.46; N, 20.56; O, 16.07; S, 4.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: B 4162; B4162; B-4162

IUPAC/Chemical Name: L-Arginine, N2-(N-(N-(N-(N-(N-(1-(1-(N2-D-arginyl-L-arginyl)-L-prolyl)-trans-4-hydroxy-L-prolyl)glycyl)-3-(2-thienyl)-L-alanyl)-L-seryl)-D-phenylalanyl)-3-(2-thienyl)-L-alanyl)-

InChi Key: MHBUKMPYIGAURU-WIDHDRDXSA-N

InChi Code: InChI=1S/C56H83N19O13S2/c57-35(13-4-17-66-53(60)61)45(80)71-38(14-5-18-67-54(62)63)50(85)74-20-6-15-42(74)44(79)34(16-19-68-55(64)65)56(52(87)88,43(78)28-70-47(82)39-24-31(77)27-69-39)75(49(84)37(59)26-33-12-8-22-90-33)51(86)40(23-30-9-2-1-3-10-30)72-48(83)41(29-76)73-46(81)36(58)25-32-11-7-21-89-32/h1-3,7-12,21-22,31,34-42,69,76-77H,4-6,13-20,23-29,57-59H2,(H,70,82)(H,71,80)(H,72,83)(H,73,81)(H,87,88)(H4,60,61,66)(H4,62,63,67)(H4,64,65,68)/t31-,34?,35-,36+,37+,38+,39+,40-,41+,42+,56-/m1/s1

SMILES Code: N[C@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)C(CCNC(=N)N)[C@](N(C(=O)[C@@H](N)Cc2cccs2)C(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc4cccs4)(C(=O)O)C(=O)CNC(=O)[C@@H]5C[C@@H](O)CN5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 1294.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Haley JE, Dickenson AH, Schachter M. Electrophysiological evidence for a role of bradykinin in chemical nociception in the rat. Neurosci Lett. 1989 Feb 13;97(1-2):198-202. doi: 10.1016/0304-3940(89)90163-8. PMID: 2537479.

2. Pellacani A, Brunner HR, Nussberger J. Antagonizing and measurement: approaches to understanding of hemodynamic effects of kinins. J Cardiovasc Pharmacol. 1992;20 Suppl 9:S28-34. doi: 10.1097/00005344-199200209-00007. PMID: 1282626.

3. Aubert JF, Waeber B, Nussberger J, Vavrek R, Stewart JM, Brunner HR. Influence of endogenous bradykinin on acute blood pressure response to vasopressors in normotensive rats assessed with a bradykinin antagonist. J Cardiovasc Pharmacol. 1988 Jan;11(1):51-5. doi: 10.1097/00005344-198801000-00008. PMID: 2450256.