JHU 37160
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463296

CAS#: 2369979-68-8

Description: JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. It is a brain penetrant in mice, rats and non-human primates.

Chemical Structure

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JHU 37160
CAS# 2369979-68-8
Instruction

Theoretical Analysis

MedKoo Cat#: 463296
Name: JHU 37160
CAS#: 2369979-68-8
Chemical Formula: C19H20ClFN4
Exact Mass: 358.14
Molecular Weight: 358.845
Elemental Analysis: C, 63.60; H, 5.62; Cl, 9.88; F, 5.29; N, 15.61

Price and Availability

Size Price Availability Quantity
5mg USD 300 2 Weeks
25mg USD 750 2 Weeks
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Synonym: JHU 37160; JHU37160; JHU-37160;

IUPAC/Chemical Name: 8-chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine

InChi Key: SWSCWOSASZXIRK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3

SMILES Code: CCN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=C(F)C=CC=C24

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 358.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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