E 4080

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463281

CAS#: 127404-34-6

Description: E 4080 is a novel bradycardic agent with a coronary vasodilating property.

Chemical Structure

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E 4080
CAS# 127404-34-6
Instruction

Theoretical Analysis

MedKoo Cat#: 463281
Name: E 4080
CAS#: 127404-34-6
Chemical Formula: C27H36Cl2N4O3
Exact Mass: 534.22
Molecular Weight: 535.510
Elemental Analysis: C, 60.56; H, 6.78; Cl, 13.24; N, 10.46; O, 8.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: E 4080; E4080; E-4080;

IUPAC/Chemical Name: (E)-4-(4-(1H-imidazol-1-yl)phenyl)-N-(3-((3,5-dimethoxyphenethyl)(methyl)amino)propyl)but-3-enamide dihydrochloride

InChi Key: KKUNFGOKUGASRQ-SLNOCBGISA-N

InChi Code: InChI=1S/C27H34N4O3.2ClH/c1-30(16-12-23-18-25(33-2)20-26(19-23)34-3)15-5-13-29-27(32)7-4-6-22-8-10-24(11-9-22)31-17-14-28-21-31;;/h4,6,8-11,14,17-21H,5,7,12-13,15-16H2,1-3H3,(H,29,32);2*1H/b6-4+;;

SMILES Code: COc1cc(OC)cc(CCN(CCCNC(C/C=C/c2ccc(n3cncc3)cc2)=O)C)c1.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 535.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Adachi H. Effects of E4080, a novel bradycardic agent with a coronary vasodilating property, on coronary and systemic hemodynamics in conscious dogs. J Pharmacol Exp Ther. 1994 Jan;268(1):133-8. PMID: 8301548.

2: Sawaki S, Furukawa Y, Inoue Y, Oguchi T, Chiba S. Selective inhibition by E4080, a novel bradycardic agent, of positive chronotropic responses to norepinephrine in isolated dog hearts. Eur J Pharmacol. 1993 Dec 7;250(2):253-9. doi: 10.1016/0014-2999(93)90389-y. PMID: 7509284.

3: Kodama K, Adachi H, Ogawa T, Ohhara H. Inhibitory effect of a novel antianginal agent, E4080, on ST segment elevation induced by vasopressin in anesthetized guinea pigs. Jpn J Pharmacol. 1992 Oct;60(2):73-7. doi: 10.1254/jjp.60.73. PMID: 1479745.

4: Okada Y, Yanagisawa T, Taira N. E4080 has a dual action, as a K+ channel opener and a Ca2+ channel blocker, in canine coronary artery smooth muscle. Eur J Pharmacol. 1992 Aug 6;218(2-3):259-64. doi: 10.1016/0014-2999(92)90177-6. PMID: 1330597.

5: Kamouchi M, Xiong Z, Teramoto N, Kajioka S, Okabe K, Kitamura K. Ionic currents involved in vasodilating actions of E4080, a newly synthesized bradycardia-inducing agent, in dispersed smooth muscle cells of the rabbit portal vein. J Pharmacol Exp Ther. 1991 Dec;259(3):1396-403. PMID: 1762086.

6: Kawamura T, Adachi H, Ogawa T. Cardiovascular effects of E4080, a novel bradycardiac agent with coronary vasodilating properties, in anesthetized dogs. Eur J Pharmacol. 1991 Oct 22;203(3):399-404. doi: 10.1016/0014-2999(91)90897-y. PMID: 1773825.