WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574949
CAS#: 165800-07-7 (disodium hydrate)
Description: Zoledronate disodium hydrate, also known as Zoledronic Acid Disodium Salt Tetrahydrate, is a biphosphonate bone resorption inhibitor.
MedKoo Cat#: 574949
Name: Zoledronate disodium hydrate
CAS#: 165800-07-7 (disodium hydrate)
Chemical Formula: C5H16N2Na2O11P2
Exact Mass:
Molecular Weight: 388.1131
Elemental Analysis: C, 15.47; H, 4.16; N, 7.22; Na, 11.85; O, 45.34; P, 15.96
Related CAS #: 118072-93-8 (free acid) 165800-06-6 (free acid hydrate) 131654-46-1 (disodium) 827573-11-5 (trisodium) 165800-07-7 (disodium hydrate) 165800-08-8 (trisodium hydrate)
Synonym: Zoledronic Acid Disodium Salt Tetrahydrate; Zoledronate Disodium, Zoledronate disodium hydrate; CGP-42446A; CGP 42446A; CGP42446A;
IUPAC/Chemical Name: Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-, disodium salt, tetrahydrate
InChi Key: IEJZOPBVBXAOBH-UHFFFAOYSA-L
InChi Code: InChI=1S/C5H10N2O7P2.2Na.4H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;;;;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);;;4*1H2/q;2*+1;;;;/p-2
SMILES Code: OC(P([O-])([O-])=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 388.1131 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Hortobagyi GN, Van Poznak C, Harker WG, Gradishar WJ, Chew H, Dakhil SR, Haley BB, Sauter N, Mohanlal R, Zheng M, Lipton A. Continued Treatment Effect of Zoledronic Acid Dosing Every 12 vs 4 Weeks in Women With Breast Cancer Metastatic to Bone: The OPTIMIZE-2 Randomized Clinical Trial. JAMA Oncol. 2017 Jul 1;3(7):906-912. doi: 10.1001/jamaoncol.2016.6316. PMID: 28125763; PMCID: PMC5824238.
