E 4695

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463216

CAS#: 132832-30-5

Description: E-4695 is a new C-7 azetidinyl fluoronaphthyridine with enhanced activity against gram-positive and anaerobic pathogens.

Chemical Structure

E 4695
CAS# 132832-30-5

Theoretical Analysis

MedKoo Cat#: 463216
Name: E 4695
CAS#: 132832-30-5
Chemical Formula: C16H17FN4O3
Exact Mass: 332.1285
Molecular Weight: 332.3354
Elemental Analysis: C, 57.83; H, 5.16; F, 5.72; N, 16.86; O, 14.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: E 4695; E4695; E-4695;

IUPAC/Chemical Name: 7-((2S,3R)-3-amino-2-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid


InChi Code: InChI=1S/C16H17FN4O3/c1-7-12(18)6-20(7)15-11(17)4-9-13(22)10(16(23)24)5-21(8-2-3-8)14(9)19-15/h4-5,7-8,12H,2-3,6,18H2,1H3,(H,23,24)/t7-,12+/m0/s1

SMILES Code: C[C@H]1[C@@H](CN1c2c(F)cc3c(N(C4CC4)C=C(C3=O)C(O)=O)n2)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 332.3354 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Guinea J, Gargallo-Viola D, Robert M, Tudela E, Xicota MA, Garcia J, Esteve M, Coll R, Pares M, Roser R. E-4695, a new C-7 azetidinyl fluoronaphthyridine with enhanced activity against gram-positive and anaerobic pathogens. Antimicrob Agents Chemother. 1995 Feb;39(2):413-21. doi: 10.1128/aac.39.2.413. PMID: 7726507; PMCID: PMC162552.

2: Mirelis B, Miró E, Navarro F, Prats G. In-vitro activity of E-4695, a new fluoronaphthyridine antimicrobial agent. J Antimicrob Chemother. 1994 May;33(5):1017-23. doi: 10.1093/jac/33.5.1017. PMID: 8089047.

3: Gooding BB, Erwin ME, Barrett MS, Johnson DM, Jones RN. Antimicrobial activities of two investigational fluoroquinolones (CI-960 and E4695) against over 100 Legionella sp. isolates. Antimicrob Agents Chemother. 1992 Sep;36(9):2049-50. doi: 10.1128/aac.36.9.2049. PMID: 1329642; PMCID: PMC192436.

4: Jones RN. In vitro evaluation of E-4695, a new fluoro-naphthyridine. Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):188-94. doi: 10.1007/BF01967076. PMID: 1327787.