WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463216
Description: E-4695 is a new C-7 azetidinyl fluoronaphthyridine with enhanced activity against gram-positive and anaerobic pathogens.
MedKoo Cat#: 463216
Name: E 4695
Chemical Formula: C16H17FN4O3
Exact Mass: 332.1285
Molecular Weight: 332.3354
Elemental Analysis: C, 57.83; H, 5.16; F, 5.72; N, 16.86; O, 14.44
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: E 4695; E4695; E-4695;
IUPAC/Chemical Name: 7-((2S,3R)-3-amino-2-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
InChi Key: AUJKWLGOXRSXRX-JVXZTZIISA-N
InChi Code: InChI=1S/C16H17FN4O3/c1-7-12(18)6-20(7)15-11(17)4-9-13(22)10(16(23)24)5-21(8-2-3-8)14(9)19-15/h4-5,7-8,12H,2-3,6,18H2,1H3,(H,23,24)/t7-,12+/m0/s1
SMILES Code: C[C@H]1[C@@H](CN1c2c(F)cc3c(N(C4CC4)C=C(C3=O)C(O)=O)n2)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 332.3354 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Guinea J, Gargallo-Viola D, Robert M, Tudela E, Xicota MA, Garcia J, Esteve M, Coll R, Pares M, Roser R. E-4695, a new C-7 azetidinyl fluoronaphthyridine with enhanced activity against gram-positive and anaerobic pathogens. Antimicrob Agents Chemother. 1995 Feb;39(2):413-21. doi: 10.1128/aac.39.2.413. PMID: 7726507; PMCID: PMC162552.
2: Mirelis B, Miró E, Navarro F, Prats G. In-vitro activity of E-4695, a new fluoronaphthyridine antimicrobial agent. J Antimicrob Chemother. 1994 May;33(5):1017-23. doi: 10.1093/jac/33.5.1017. PMID: 8089047.
3: Gooding BB, Erwin ME, Barrett MS, Johnson DM, Jones RN. Antimicrobial activities of two investigational fluoroquinolones (CI-960 and E4695) against over 100 Legionella sp. isolates. Antimicrob Agents Chemother. 1992 Sep;36(9):2049-50. doi: 10.1128/aac.36.9.2049. PMID: 1329642; PMCID: PMC192436.
4: Jones RN. In vitro evaluation of E-4695, a new fluoro-naphthyridine. Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):188-94. doi: 10.1007/BF01967076. PMID: 1327787.