Hydromethylthionine HBr
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MedKoo CAT#: 330057

CAS#: 951131-15-0 (HBr)

Description: Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 650 2 Weeks
200mg USD 1050 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 4650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-12-02. Prices are subject to change without notice.

Hydromethylthionine HBr is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 330057
Name: Hydromethylthionine HBr
CAS#: 951131-15-0 (HBr)
Chemical Formula: C16H21Br2N3S
Exact Mass:
Molecular Weight: 447.233
Elemental Analysis: C, 42.97; H, 4.73; Br, 35.73; N, 9.40; S, 7.17


Related CAS #: 613-11-6 (free base)   1236208-20-0 (mesylate)   61-73-4 (chloride)   951131-15-0 (HBr)    

Synonym: Hydromethylthionine HBr; TRX-0237 HBr; TRX-0237 dihydrobromide; TRX0237; TRX 0237; Leucomethylene Blue dihydrobromide; Leukomethylene Blue dihydrobromide; Reduced methylene Blue dihydrobromide;

IUPAC/Chemical Name: N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dihydrobromide

InChi Key: JAUPSVVTGFBHTN-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19N3S.2BrH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10,17H,1-4H3;2*1H

SMILES Code: CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1.[H]Br.[H]Br


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Shiells H, Schelter BO, Bentham P, Baddeley TC, Rubino CM, Ganesan H, Hammel J, Vuksanovic V, Staff RT, Murray AD, Bracoud L, Wischik DJ, Riedel G, Gauthier S, Jia J, Moebius HJ, Hardlund J, Kipps CM, Kook K, Storey JMD, Harrington CR, Wischik CM. Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia. J Alzheimers Dis. 2020;75(2):501-519. doi: 10.3233/JAD-191173. PMID: 32280089; PMCID: PMC7306898.

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