WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574947

CAS#: 4452-06-6

Description: ZM-449829 is an inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site and inhibits STAT-5 phosphorylation and T cell proliferation.

Chemical Structure

CAS# 4452-06-6

Theoretical Analysis

MedKoo Cat#: 574947
Name: ZM-449829
CAS#: 4452-06-6
Chemical Formula: C13H10O
Exact Mass: 182.0732
Molecular Weight: 182.22
Elemental Analysis: C, 85.69; H, 5.53; O, 8.78

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
10.0mg USD 450.0 2 Weeks
25.0mg USD 800.0 2 Weeks
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Synonym: ZM-449829; ZM 449829; ZM449829

IUPAC/Chemical Name: 1-(2-Naphthalenyl)-2-propen-1-one


InChi Code: InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 182.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557

2. Orange et al (2011) IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 121 1535 PMID: 21383498