Y27632 HCl hydrate

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MedKoo CAT#: 574938

CAS#: 331752-47-7 (HCl hydrate)

Description: Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord.

Chemical Structure

Y27632 HCl hydrate
CAS# 331752-47-7 (HCl hydrate)

Theoretical Analysis

MedKoo Cat#: 574938
Name: Y27632 HCl hydrate
CAS#: 331752-47-7 (HCl hydrate)
Chemical Formula: C14H25Cl2N3O2
Exact Mass: 0.00
Molecular Weight: 338.270
Elemental Analysis: C, 49.71; H, 7.45; Cl, 20.96; N, 12.42; O, 9.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Related CAS #: 331752-47-7 (HCl hydrate), 129830-38-2 (2HCl), 146986-50-7 (free base), 138381-45-0 (racemate HCl), 310898-86-3 (recamte free base),

Synonym: Y-27632 dihydrochloride hydrate; Y27632 HCl hydrate; Y27632; Y-27632; Y 27632;

IUPAC/Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide dihydrochloride monohydrate


InChi Code: InChI=1S/C14H21N3O.2ClH.H2O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H;1H2/t10-,11-,12-;;;/m1.../s1

SMILES Code: O=C([C@H]1CC[C@H]([C@H](N)C)CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in water

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in water

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 14.0 41.39

Preparing Stock Solutions

The following data is based on the product molecular weight 338.270000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Wang T, Kang W, Du L, Ge S. Rho-kinase inhibitor Y-27632 facilitates the proliferation, migration and pluripotency of human periodontal ligament stem cells. J Cell Mol Med. 2017 Nov;21(11):3100-3112. doi: 10.1111/jcmm.13222. Epub 2017 Jun 29. PMID: 28661039; PMCID: PMC5661246. 2. Zhao M, Fan C, Ernst PJ, Tang Y, Zhu H, Mattapally S, Oduk Y, Borovjagin AV, Zhou L, Zhang J, Zhu W. Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice. Cardiovasc Res. 2019 Feb 1;115(2):343-356. doi: 10.1093/cvr/cvy207. PMID: 30107391; PMCID: PMC6341224.