LC3-mHTT-IN-AN1
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555872

CAS#: 486443-73-6

Description: LC3-mHTT-IN-AN1 is a HTT-LC3 linker compound. LC3-mHTT-IN-AN1 interacts with both LC3 and mHTT, but not with the wild-type HTT protein. LC3-mHTT-IN-AN1 reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease


Chemical Structure

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LC3-mHTT-IN-AN1
CAS# 486443-73-6

Theoretical Analysis

MedKoo Cat#: 555872
Name: LC3-mHTT-IN-AN1
CAS#: 486443-73-6
Chemical Formula: C15H9Br2NO3
Exact Mass: 408.8949
Molecular Weight: 411.049
Elemental Analysis: C, 43.83; H, 2.21; Br, 38.88; N, 3.41; O, 11.68

Price and Availability

Size Price Availability Quantity
100.0mg USD 1450.0 2 Weeks
200.0mg USD 2150.0 2 Weeks
500.0mg USD 3050.0 2 Weeks
1.0g USD 4250.0 2 Weeks
2.0g USD 6950.0 2 Weeks
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Synonym: LC3-mHTT-IN-AN1

IUPAC/Chemical Name: (Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one

InChi Key: GPKLWRHHVIBYEO-KMKOMSMNSA-N

InChi Code: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-

SMILES Code: BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 411.049 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. doi: 10.1038/s41586-019-1722-1. Epub 2019 Oct 30. PMID: 31666698.



Additional Information

Accumulation of mutant proteins is a major cause of many diseases (collectively called proteopathies), and lowering the level of these proteins can be useful for treatment of these diseases.