WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555872
Description: LC3-mHTT-IN-AN1 is a HTT-LC3 linker compound. LC3-mHTT-IN-AN1 interacts with both LC3 and mHTT, but not with the wild-type HTT protein. LC3-mHTT-IN-AN1 reduced mHTT levels in an allele-selective manner, and rescued disease-relevant phenotypes in cells and in vivo in fly and mouse models of Huntington's disease
MedKoo Cat#: 555872
Chemical Formula: C15H9Br2NO3
Exact Mass: 408.8949
Molecular Weight: 411.049
Elemental Analysis: C, 43.83; H, 2.21; Br, 38.88; N, 3.41; O, 11.68
IUPAC/Chemical Name: (Z)-5-bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
InChi Key: GPKLWRHHVIBYEO-KMKOMSMNSA-N
InChi Code: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-
SMILES Code: BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
Accumulation of mutant proteins is a major cause of many diseases (collectively called proteopathies), and lowering the level of these proteins can be useful for treatment of these diseases.
Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. doi: 10.1038/s41586-019-1722-1. Epub 2019 Oct 30. PMID: 31666698.