WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555867
Description: SJA710-6 is a Hepatic Differentiation Inducer which is able to induce the differentiation of rat MSCs (rMSCs) toward hepatocyte-like cells in vitro, where rMSCs treated with SJA710-6 have typical morphological and functional characteristics of hepatic cells, including glycogen storage, urea secretion, uptake of low density lipoprotein (LDL) and expression of hepatocyte-specific genes and proteins. Expression of FoxH1 (FAST1/2) induces the differentiation of rMSCs towards hepatocyte-like cells, suggesting that this gene plays an important role in the hepatic fate specification of rMSCs.
MedKoo Cat#: 555867
Chemical Formula: C22H20BrFN4
Exact Mass: 438.0855
Molecular Weight: 439.3324
Elemental Analysis: C, 60.15; H, 4.59; Br, 18.19; F, 4.32; N, 12.75
Synonym: SJA710-6; SJA-710-6; SJA 710-6; SJA7106; SJA-7106; SJA 7106;
IUPAC/Chemical Name: 2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine
InChi Key: RPNQWWSSADJSGS-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H20BrFN4/c1-2-13-28-21(16-5-7-17(23)8-6-16)26-19-11-12-20(27-22(19)28)25-14-15-3-9-18(24)10-4-15/h3-12H,2,13-14H2,1H3,(H,25,27)
SMILES Code: CCCN1C(C2=CC=C(Br)C=C2)=NC3=CC=C(NCC4=CC=C(F)C=C4)N=C31
Mesenchymal stem cells (MSCs) are capable of self-renewal and multilineage differentiation. A periodic acid-Schiff (PAS) stain-based assay was developed to screen for small-molecule inducers of hepatic differentiation of bone marrow MSCs.
Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.