SJA710-6
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555867

CAS#: 1397255-09-2

Description: SJA710-6 is a hepatic differentiation inducer.


Chemical Structure

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SJA710-6
CAS# 1397255-09-2

Theoretical Analysis

MedKoo Cat#: 555867
Name: SJA710-6
CAS#: 1397255-09-2
Chemical Formula: C22H20BrFN4
Exact Mass: 438.09
Molecular Weight: 439.330
Elemental Analysis: C, 60.15; H, 4.59; Br, 18.19; F, 4.32; N, 12.75

Price and Availability

Size Price Availability Quantity
50mg USD 350 2 Weeks
100mg USD 550 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 4650 2 Weeks
5g USD 6950 2 Weeks
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Synonym: SJA710-6; SJA-710-6; SJA 710-6; SJA7106; SJA-7106; SJA 7106;

IUPAC/Chemical Name: 2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine

InChi Key: RPNQWWSSADJSGS-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20BrFN4/c1-2-13-28-21(16-5-7-17(23)8-6-16)26-19-11-12-20(27-22(19)28)25-14-15-3-9-18(24)10-4-15/h3-12H,2,13-14H2,1H3,(H,25,27)

SMILES Code: CCCN1C(C2=CC=C(Br)C=C2)=NC3=CC=C(NCC4=CC=C(F)C=C4)N=C31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Mesenchymal stem cells (MSCs) are capable of self-renewal and multilineage differentiation. A periodic acid-Schiff (PAS) stain-based assay was developed to screen for small-molecule inducers of hepatic differentiation of bone marrow MSCs.

Product Data:
Biological target: SJA710-6 selectively differentiates MSCs toward hepatocyte-like cells.
In vitro activity: SJA710-6 was able to induce the differentiation of rMSCs toward hepatocyte-like cells in vitro. rMSCs treated with SJA710-6 had typical morphological and functional characteristics of hepatic cells, including glycogen storage, urea secretion, uptake of low density lipoprotein (LDL) and expression of hepatocyte-specific genes and proteins. Reference: ChemMedChem. 2012 Aug;7(8):1447-52. https://pubmed.ncbi.nlm.nih.gov/22715131/
In vivo activity: SJA6017 may have potential in spinal cord injury treatment. In a rat spinal cord injury model, SJA6017 reduced apoptotic cell death, preserved spinal cord tissue and improved functional outcome. SJA6017 treated rats had significantly reduced tissue injury and had ameliorated recovery of limb function. Reference: J Clin Neurosci. 2008 Oct;15(10):1130-6. https://pubmed.ncbi.nlm.nih.gov/18656362/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 250.0 569.06

Preparing Stock Solutions

The following data is based on the product molecular weight 439.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.
In vitro protocol: 1. Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.
In vivo protocol: To be determined

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Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.