SJA710-6
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MedKoo CAT#: 555867

CAS#: 1397255-09-2

Description: SJA710-6 is a Hepatic Differentiation Inducer which is able to induce the differentiation of rat MSCs (rMSCs) toward hepatocyte-like cells in vitro, where rMSCs treated with SJA710-6 have typical morphological and functional characteristics of hepatic cells, including glycogen storage, urea secretion, uptake of low density lipoprotein (LDL) and expression of hepatocyte-specific genes and proteins. Expression of FoxH1 (FAST1/2) induces the differentiation of rMSCs towards hepatocyte-like cells, suggesting that this gene plays an important role in the hepatic fate specification of rMSCs.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 350 2 Weeks
100mg USD 550 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 4650 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-12-02. Prices are subject to change without notice.

SJA710-6 is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555867
Name: SJA710-6
CAS#: 1397255-09-2
Chemical Formula: C22H20BrFN4
Exact Mass: 438.0855
Molecular Weight: 439.3324
Elemental Analysis: C, 60.15; H, 4.59; Br, 18.19; F, 4.32; N, 12.75


Synonym: SJA710-6; SJA-710-6; SJA 710-6; SJA7106; SJA-7106; SJA 7106;

IUPAC/Chemical Name: 2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine

InChi Key: RPNQWWSSADJSGS-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20BrFN4/c1-2-13-28-21(16-5-7-17(23)8-6-16)26-19-11-12-20(27-22(19)28)25-14-15-3-9-18(24)10-4-15/h3-12H,2,13-14H2,1H3,(H,25,27)

SMILES Code: CCCN1C(C2=CC=C(Br)C=C2)=NC3=CC=C(NCC4=CC=C(F)C=C4)N=C31


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Mesenchymal stem cells (MSCs) are capable of self-renewal and multilineage differentiation. A periodic acid-Schiff (PAS) stain-based assay was developed to screen for small-molecule inducers of hepatic differentiation of bone marrow MSCs.


References

Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.