Trequinsin hydrochloride
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MedKoo CAT#: 574922

CAS#: 78416-81-6

Description: Trequinsin hydrochloride is a phosphodiesterase (PDE) 3 inhibitor that is dependent on cyclic AMP (cAMP). Trequinsin HCl stimulates cAMP accumulation and increases cell membrane capacitance.

Chemical Structure

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Trequinsin hydrochloride
CAS# 78416-81-6
Instruction

Theoretical Analysis

MedKoo Cat#: 574922
Name: Trequinsin hydrochloride
CAS#: 78416-81-6
Chemical Formula: C24H28ClN3O3
Exact Mass: 441.18
Molecular Weight: 441.960
Elemental Analysis: C, 65.22; H, 6.39; Cl, 8.02; N, 9.51; O, 10.86

Price and Availability

Size Price Availability Quantity
1mg USD 215 2 Weeks
5mg USD 450 2 Weeks
10mg USD 680 2 Weeks
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Synonym: Trequinsin hydrochloride; Trequinsin HCl

IUPAC/Chemical Name: 2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one, monohydrochloride

InChi Key: DTCZZBVPTHVXFA-OSMRDGEFSA-N

InChi Code: InChI=1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22+;

SMILES Code: O=C(N/1C)N2CCC3=CC(OC)=C(OC)C=C3C2=CC1=N/C4=C(C)C=C(C)C=C4C.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 441.960000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Liu, S., Veilleux, A., Zhang, L., et al. Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors. J. Pharmacol. Exp. Ther. 314(2), 846-854 (2005). 2. Friis, U.G., Jensen, B.L., Sethi, S., et al. Control of renin secretion from rat juxtaglomerular cells by cAMP-specific phosphodiesterases. Circ. Res. 90(9), 996-1003 (2002). 3. Jedlitschky, G., Burchell, B., and Keppler, D. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J. Biol. Chem. 275(39), 30069-30074 (2000). 4. Darius, H., Lefer, A.M., Leprán, I., et al. In vivo interaction of prostacyclin with an inhibitor of cyclic nucleotide phosphodiesterase, HL 725. Br. J. Pharmacol. 84(3), 735-741 (1985).