Triapine free base
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MedKoo CAT#: 574918

CAS#: 143621-35-6 (free base)

Description: Triapine, also known as 3-AP and OCX-191, is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro.

Chemical Structure

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Triapine free base
CAS# 143621-35-6 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 574918
Name: Triapine free base
CAS#: 143621-35-6 (free base)
Chemical Formula: C7H9N5S
Exact Mass: 195.06
Molecular Weight: 195.240
Elemental Analysis: C, 43.06; H, 4.65; N, 35.87; S, 16.42

Price and Availability

Size Price Availability Quantity
10mg USD 450 2 Weeks
25mg USD 950 2 Weeks
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Related CAS #: 200933-27-3 (E-isomer)   143621-35-6 (free base)   236392-56-6 (deleted)   216240-62-9 (HCl)   1938041-34-9 (HCl hydrate)    

Synonym: 3AP; 3AP; 3Apct; OCX 191; OCX191; OCX191; AIDS179996; AIDS179996; NSC663249. PAN-811; PAN811; PAN 811; Triapine

IUPAC/Chemical Name: (E)-2-((3-aminopyridin-2-yl)methylene)hydrazine-1-carbothioamide

InChi Key: XMYKNCNAZKMVQN-NYYWCZLTSA-N

InChi Code: InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+

SMILES Code: NC1=C(/C=N/NC(N)=S)N=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 195.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Lin ZP, Zhu YL, Lo YC, Moscarelli J, Xiong A, Korayem Y, Huang PH, Giri S, LoRusso P, Ratner ES. Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer. PLoS One. 2018 Nov 16;13(11):e0207399. doi: 10.1371/journal.pone.0207399. PMID: 30444904; PMCID: PMC6239325.