Triacsin C
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MedKoo CAT#: 574917

CAS#: 76896-80-5

Description: Triacsin C is an inhibitor of long fatty acid acyl-CoA synthetase. It is also known to act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.

Chemical Structure

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Triacsin C
CAS# 76896-80-5
Instruction

Theoretical Analysis

MedKoo Cat#: 574917
Name: Triacsin C
CAS#: 76896-80-5
Chemical Formula: C11H17N3O
Exact Mass: 207.14
Molecular Weight: 207.280
Elemental Analysis: C, 63.74; H, 8.27; N, 20.27; O, 7.72

Price and Availability

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1mg USD 600 2 Weeks
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Synonym: FR 900190; Triacsin C; WS 1228A

IUPAC/Chemical Name: 2E,4E,7E-undecatrienal, nitrosohydrazone

InChi Key: NKTGCVUIESDXPU-YLEPRARLSA-N

InChi Code: InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+

SMILES Code: CCC/C=C/C/C=C/C=C/C=N/NN=O

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
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Preparing Stock Solutions

The following data is based on the product molecular weight 207.280000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Tomoda, H., Igarashi, K., Cyong, J.C., et al. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. The Journal of Biological Chemisty 266, 4214-4219 (1991). 2. Igal, R.A., Wang, P., and Coleman, R.A. Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: Evidence for functionally separate pools of acyl-CoA. Biochemistry Journal 324(Pt 2), 529-534 (1997). 3. Weis, M.T., Crumley, J.L., Young, L.H., et al. Inhibiting long chain fatty acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium. Cardiovascular Research 63(2), 338-346 (2004). 4. Zhao, Y., Wang, L., Qiu, J., et al. Linoleic acid stimulates [Ca2+]i increase in rat pancreaticβcells through both membrane receptor- and intracellular metabolite-mediated pathways. PLoS One 8(4), e60255 (2013).