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MedKoo CAT#: 555862

CAS#: 259674-19-6

Description: HVN74196, also known as TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. HVN74196 has CAS#259674-19-6, no formal name. For the convenience of scientific communication, we named it as HVN74196 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature).

Price and Availability

Size Price Shipping out time Quantity
100mg USD 550 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 4650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

HVN74196 is in stock

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555862
Name: HVN74196
CAS#: 259674-19-6
Chemical Formula: C26H26N2O2
Exact Mass: 398.1994
Molecular Weight: 398.506
Elemental Analysis: C, 78.36; H, 6.58; N, 7.03; O, 8.03

Synonym: TRPM8 antagonist 2; HVN74196; HVN-74196; HVN 74196;

IUPAC/Chemical Name: methyl Na,Na-dibenzyl-L-tryptophanate


InChi Code: InChI=1S/C26H26N2O2/c1-30-26(29)25(16-22-17-27-24-15-9-8-14-23(22)24)28(18-20-10-4-2-5-11-20)19-21-12-6-3-7-13-21/h2-15,17,25,27H,16,18-19H2,1H3/t25-/m0/s1


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


[1]. Bertamino A, et al. Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. J Med Chem. 2018 Jul 10. doi: 10.1021/acs.jmedchem.8b00545.