WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463152
CAS#: 2407654-51-5
Description: ZXH-1-161 is a novel Selective Degrader of GSPT1. Due to its potency and selectivity for GSPT1, ZXH-1-161 is a superior tool to CC-885 for exploring the therapeutic potential of GSPT1 degradation and may provide additional opportunities for therapeutically targeting GSPT1, where a degradation-based strategy has already shown potential in the treatment of acute myeloid leukemia (AML).
MedKoo Cat#: 463152
Name: ZXH-1-161
CAS#: 2407654-51-5
Chemical Formula: C26H24N6O3
Exact Mass: 468.191
Molecular Weight: 468.52
Elemental Analysis: C, 66.65; H, 5.16; N, 17.94; O, 10.24
This product is not in stock, which may be available by custom synthesis.
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Synonym: ZXH-1-161; ZXH1-161; ZXH 1-161; ZXH-1161 ZXH-1 161; ZXH1161; ZXH 1 161;
IUPAC/Chemical Name: 3-(4-((2-((2,3-dihydro-1H-inden-5-yl)amino)pyrimidin-4-yl)amino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
InChi Key: KCIIVRZRNLZKQA-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H24N6O3/c33-23-10-9-21(24(34)31-23)32-14-19-18(25(32)35)5-2-6-20(19)29-22-11-12-27-26(30-22)28-17-8-7-15-3-1-4-16(15)13-17/h2,5-8,11-13,21H,1,3-4,9-10,14H2,(H,31,33,34)(H2,27,28,29,30)
SMILES Code: O=C1N(CC2=C(NC3=NC(NC4=CC5=C(C=C4)CCC5)=NC=C3)C=CC=C21)C6CCC(NC6=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 468.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
https://pubs.acs.org/doi/10.1021/acschembio.0c00520
Cereblon (CRBN) is an E3 ligase adapter protein that can be reprogrammed by imide-class compounds such as thalidomide, lenalidomide, and pomalidomide to induce the degradation of neo-substrate proteins.
