WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463142
CAS#: unknown
Description: GHSR inverse agonist 29 is a novel nonpeptidic inverse agonist of the Ghrelin Receptor (GHSR).
MedKoo Cat#: 463142
Name: GHSR inverse agonist 29
CAS#: unknown
Chemical Formula: C40H37N7O4
Exact Mass: 679.2907
Molecular Weight: 679.781
Elemental Analysis: C, 70.68; H, 5.49; N, 14.42; O, 9.41
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Synonym: GHSR inverse agonist 29;
IUPAC/Chemical Name: (R,E)-N-(2-((2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)amino)-2-oxoethyl)-2-cyano-3-(4-hydroxyphenyl)acrylamide
InChi Key: FGNNWPMPZZXGBE-WQMHXSCVSA-N
InChi Code: InChI=1S/C40H37N7O4/c1-51-33-18-13-29(14-19-33)26-47-37(20-15-27-7-3-2-4-8-27)45-46-39(47)36(22-31-24-42-35-10-6-5-9-34(31)35)44-38(49)25-43-40(50)30(23-41)21-28-11-16-32(48)17-12-28/h2-14,16-19,21,24,36,42,48H,15,20,22,25-26H2,1H3,(H,43,50)(H,44,49)/b30-21+/t36-/m1/s1
SMILES Code: N#C/C(C(NCC(N[C@@H](C1=NN=C(CCC2=CC=CC=C2)N1CC3=CC=C(OC)C=C3)CC4=CNC5=C4C=CC=C5)=O)=O)=C\C6=CC=C(O)C=C6
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 679.781 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Daina A, Giuliano C, Pietra C, Wang J, Chi Y, Zou Z, Li F, Yan Z, Zhou Y, Guainazzi A, Garcia Rubio S, Zoete V. Rational Design, Synthesis, and Pharmacological Characterization of Novel Ghrelin Receptor Inverse Agonists as Potential Treatment against Obesity-Related Metabolic Diseases. J Med Chem. 2018 Dec 27;61(24):11039-11060. doi: 10.1021/acs.jmedchem.8b00794. Epub 2018 Oct 15. PMID: 30265805.
