Xylometazoline free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412101

CAS#: 526-36-3 (free base)

Description: Xylometazoline, also spelled xylomethazoline, is a medication used to reduce symptoms of nasal congestion, allergic rhinitis, and sinusitis. Use is not recommended for more than seven days. Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to α1 and α2 adrenergic receptors in the nasal mucosa. Due to its sympathomimetic effects, it should not be used by people with high blood pressure, or other heart problems.

Chemical Structure

Xylometazoline free base
CAS# 526-36-3 (free base)

Theoretical Analysis

MedKoo Cat#: 412101
Name: Xylometazoline free base
CAS#: 526-36-3 (free base)
Chemical Formula: C16H24N2
Exact Mass: 244.1939
Molecular Weight: 244.38
Elemental Analysis: C, 78.64; H, 9.90; N, 11.46

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1218-35-5 (HCl)   526-36-3 (free base)    

Synonym: Xylometazoline free base, BA 11391; BA-11391; BA11391;

IUPAC/Chemical Name: 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-


InChi Code: InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 244.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Patel S, Hazarika A, Agrawal P, Jain D, Panda NK. A prospective randomized trial of xylometazoline drops and epinephrine merocele nasal pack for reducing epistaxis during nasotracheal intubation. J Dent Anesth Pain Med. 2020 Aug;20(4):223-231. doi: 10.17245/jdapm.2020.20.4.223. Epub 2020 Aug 27. PMID: 32934988; PMCID: PMC7470991.

2: Dhakate VR, Singam AP, Bharadwaj HS. Evaluation of Nasopharyngeal Airway to Facilitate Nasotracheal Intubation. Ann Maxillofac Surg. 2020 Jan- Jun;10(1):57-60. doi: 10.4103/ams.ams_190_19. Epub 2020 Jun 8. PMID: 32855916; PMCID: PMC7433945.

3: Onal M, Keles B, Erdur O, Alatas N, Onal O. Effect of Hypertonic Saline during Flexible Nasopharyngeal Laryngoscopy: A Double-Blinded, Randomized, Controlled Trial. J Invest Surg. 2020 Jun 11:1-6. doi: 10.1080/08941939.2020.1777490. Epub ahead of print. PMID: 32525416.

4: Matsukawa T, Hikasa Y. Effects of imidazoline and nonimidazoline α-adrenoceptor agonists and antagonists, including xylazine, medetomidine, dexmedetomidine, yohimbine, and atipamezole, on aggregation of feline platelets. Am J Vet Res. 2020 Feb;81(2):159-171. doi: 10.2460/ajvr.81.2.159. PMID: 31985287.

5: Joshi KS, Ho VWQ, Smith ME, Tysome JR. The effect of topical xylometazoline on Eustachian tube function. J Laryngol Otol. 2020 Jan;134(1):29-33. doi: 10.1017/S0022215120000158. Epub 2020 Jan 22. PMID: 31964436.

6: Ali A, Wahlgren M, Rembratt-Svensson B, Daftani A, Falkman P, Wollmer P, Engblom J. Dehydration affects drug transport over nasal mucosa. Drug Deliv. 2019 Dec;26(1):831-840. doi: 10.1080/10717544.2019.1650848. PMID: 31401887; PMCID: PMC6713119.

7: Alaula LS, Al-Kadi M, Almajed A, Alhedaithy R. Atropine toxicity caused by erroneous intranasal administration in a pediatric patient: case report. Ann Saudi Med. 2019 Jul-Aug;39(4):279-282. doi: 10.5144/0256-4947.2019.279. Epub 2019 Aug 5. PMID: 31381360; PMCID: PMC6838643.

8: Reid JW, Rotenberg BW, Sowerby LJ. Contemporary decongestant practices of Canadian otolaryngologists for endoscopic sinus surgery. J Otolaryngol Head Neck Surg. 2019 Mar 18;48(1):15. doi: 10.1186/s40463-019-0337-8. PMID: 30885260; PMCID: PMC6421656.

9: Shamil E, Rouhani MJ, Panayi AC, Lynch J, Tysome J, Jonas N. Investigating the effect of a nasal decongestant on post-adenotonsillectomy respiratory complications in 25 paediatric patients with obstructive sleep apnoea: a pilot study. J Laryngol Otol. 2019 Feb;133(2):110-114. doi: 10.1017/S0022215119000033. Epub 2019 Feb 1. PMID: 30706841.

10: Graf C, Bernkop-Schnürch A, Egyed A, Koller C, Prieschl-Grassauer E, Morokutti-Kurz M. Development of a nasal spray containing xylometazoline hydrochloride and iota-carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and sinusitis. Int J Gen Med. 2018 Jul 4;11:275-283. doi: 10.2147/IJGM.S167123. PMID: 30013382; PMCID: PMC6037157.

11: Unsal AIA, Basal Y, Birincioglu S, Kocaturk T, Cakmak H, Unsal A, Cakiroz G, Eliyatkın N, Yukselen O, Demirci B. Ophthalmic adverse effects of nasal decongestants on an experimental rat model. Arq Bras Oftalmol. 2018 Jan- Feb;81(1):53-58. doi: 10.5935/0004-2749.20180012. PMID: 29538595.

12: Song J. A comparison of the effects of epinephrine and xylometazoline in decreasing nasal bleeding during nasotracheal intubation. J Dent Anesth Pain Med. 2017 Dec;17(4):281-287. doi: 10.17245/jdapm.2017.17.4.281. Epub 2017 Dec 28. PMID: 29349350; PMCID: PMC5766085.

13: Red. Xylometazolin plus Dexpanthenol gegen akute Rhinitis. MMW Fortschr Med. 2018 Jan;160(1):68. German. doi: 10.1007/s15006-018-0098-8. PMID: 29335936.

14: Haldar R, Bajwa SS, Kaur J. Xylometazoline nasal drops induced anaphylaxis: An atypical perioperative complication. J Anaesthesiol Clin Pharmacol. 2017 Jul- Sep;33(3):399-401. doi: 10.4103/0970-9185.173331. PMID: 29109644; PMCID: PMC5672530.

15: Joganathan V, Beigi B. Safety of the use of xylometazoline nasal spray in young children undergoing lacrimal surgery: an observational study. Eur J Ophthalmol. 2018 May;28(3):279-281. doi: 10.5301/ejo.5001054. Epub 2017 Oct 24. PMID: 29077183.

16: Mösges R, Shah-Hosseini K, Hucke HP, Joisten MJ. Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays. Adv Ther. 2017 Aug;34(8):1850-1858. doi: 10.1007/s12325-017-0581-0. Epub 2017 Jul 10. PMID: 28695477; PMCID: PMC5565656.

17: Schuenemann R, Pohl S, Oechtering GU. A novel approach to brachycephalic syndrome. 3. Isolated laser-assisted turbinectomy of caudal aberrant turbinates (CAT LATE). Vet Surg. 2017 Jan;46(1):32-38. doi: 10.1111/vsu.12587. PMID: 28052420.

18: Swoboda S, Thulesius HL, Jessen M. Paradoxical increase in nasal airway resistance after topical nasal decongestion - does it really exist? A retro- and prospective study. Clin Otolaryngol. 2016 Dec;41(6):689-693. doi: 10.1111/coa.12592. Epub 2016 Feb 19. PMID: 27870310.

19: Deckx L, De Sutter AI, Guo L, Mir NA, van Driel ML. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev. 2016 Oct 17;10(10):CD009612. doi: 10.1002/14651858.CD009612.pub2. PMID: 27748955; PMCID: PMC6461189.

20: Wang X, Johansen SS, Nielsen MKK, Linnet K. Targeted analysis of 116 drugs in hair by UHPLC-MS/MS and its application to forensic cases. Drug Test Anal. 2017 Aug;9(8):1137-1151. doi: 10.1002/dta.2130. Epub 2016 Dec 22. PMID: 27794182.