WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463099
Description: E-0702 is an antipseudomonal cephalosporin derivative which has a broad spectrum of antibacterial activity against clinical isolates of gram-positive and gram-negative bacteria. It has significantly high in vitro antibacterial activity against gram-negative bacteria including the Pseudomonas group.
MedKoo Cat#: 463099
Name: E 0702
Chemical Formula: C29H21N7Na2O12S2
Exact Mass: 769.0485
Molecular Weight: 769.6235
Elemental Analysis: C, 45.26; H, 2.75; N, 12.74; Na, 5.97; O, 24.95; S, 8.33
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Synonym: E 0702; E0702; E-0702;
IUPAC/Chemical Name: sodium (6R,7R)-3-(((1-(carboxylatomethyl)-1H-tetrazol-5-yl)thio)methyl)-7-(2-(6,7-dihydroxy-4-oxo-4H-chromene-3-carboxamido)-2-(4-hydroxyphenyl)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key: HJWFZVYGOATFNO-RPGKBGGYSA-L
InChi Code: InChI=1S/C29H23N7O12S2.2Na/c37-13-3-1-11(2-4-13)20(30-24(43)15-8-48-18-6-17(39)16(38)5-14(18)23(15)42)25(44)31-21-26(45)36-22(28(46)47)12(9-49-27(21)36)10-50-29-32-33-34-35(29)7-19(40)41;;/h1-6,8,20-21,27,37-39H,7,9-10H2,(H,30,43)(H,31,44)(H,40,41)(H,46,47);;/q;2*+1/p-2/t20?,21-,27-;;/m1../s1
SMILES Code: O=C(C(N12)=C(CSC3=NN=NN3CC([O-])=O)CS[C@]2([H])[C@H](NC(C(NC(C4=COC5=CC(O)=C(O)C=C5C4=O)=O)C6=CC=C(O)C=C6)=O)C1=O)[O-].[Na+].[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 769.6235 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Watanabe NA, Nagasu T, Katsu K, Kitoh K. E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system. Antimicrob Agents Chemother. 1987 Apr;31(4):497-504. doi: 10.1128/aac.31.4.497. PMID: 3037997; PMCID: PMC174766.
2: Neu HC, Labthavikul P. In vitro antibacterial activity and beta-lactamase stability of E-0702, a new cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):313-20. doi: 10.1128/aac.24.3.313. PMID: 6605718; PMCID: PMC185318.
3: Katsu K, Kitoh K, Inoue M, Mitsuhashi S. In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin. Antimicrob Agents Chemother. 1982 Aug;22(2):181-5. doi: 10.1128/aac.22.2.181. PMID: 6100421; PMCID: PMC183706.