WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463049
CAS#: 89845-17-0
Description: Gastrofenzin is an antiulcer drug. It has also been shown to exhibit gonadotropic effects.
MedKoo Cat#: 463049
Name: Gastrofenzin
CAS#: 89845-17-0
Chemical Formula: C19H22Cl2N2O2
Exact Mass: 380.1058
Molecular Weight: 381.297
Elemental Analysis: C, 59.85; H, 5.82; Cl, 18.59; N, 7.35; O, 8.39
This product is not in stock, which may be available by custom synthesis.
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Synonym: Gastrofenzin; Gastrophenzine; Gastrophensin;
IUPAC/Chemical Name: ethyl (4-(4-chlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-8-yl)carbamate hydrochloride
InChi Key: MYXXVPPYQMJHGO-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21ClN2O2.ClH/c1-3-24-19(23)21-18-6-4-5-15-16(11-22(2)12-17(15)18)13-7-9-14(20)10-8-13;/h4-10,16H,3,11-12H2,1-2H3,(H,21,23);1H
SMILES Code: CCOC(Nc1c2c(C(c3ccc(Cl)cc3)CN(C2)C)ccc1)=O.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 381.297 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Antov G, Zaĭkov Kh, Mikhaĭlova A, Khalkova Zh, Popov T, Tasheva M, Mitova S, Dinoeva S, Kapurgov V. Toksikologichna kharakteristika na "Gastrofenzin". III. Khronichna oralna toksichnost [The toxicological characteristics of Gastrofenzin. III. Its chronic oral toxicity]. Probl Khig. 1996;21:96-102. Bulgarian. PMID: 9190605.
2: Mikhaĭlova A, Antov G, Khalkova Zh, Zaĭkov Kh, Tasheva M, Dinoeva S. Toksikologichna kharakteristika na "Gastrofenzin". II. Podostra oralna toksichnost [The toxicological characteristics of Gastrofenzin. II. Its subacute oral toxicity]. Probl Khig. 1996;21:88-96. Bulgarian. PMID: 9190604.
3: Khalkova Zh, Zaĭkov Kh, Antov G, Mikhaĭlova A, Ivanova N. Toksikologichna kharakteristika na "Gastrofenzin". I. Ostra toksichnost (oralna, podkozhna, intravenozna) [The toxicological characteristics of Gastrofenzin. I. Its acute toxicity (oral, subcutaneous and intravenous)]. Probl Khig. 1996;21:81-8. Bulgarian. PMID: 9190603.
4: Ilieva P, Ivanova-Chemishanska L, Antov G. Toksikologichna kharakteristika na "Gastrofenzin". IV. Gonadotropno deĭstvie [The toxicological characteristics of Gastrofenzin. IV. Its gonadotropic action]. Probl Khig. 1996;21:102-6. Bulgarian. PMID: 9190585.
5: Mirkova E. Genotoksichnost i kantserogenen potentsial na gastrofenzin [The genotoxicity and carcinogenic potential of gastrofenzin]. Eksp Med Morfol. 1994;32(3-4):57-68. Bulgarian. PMID: 8857033.
6: Ivanova N, Mondeshka D, Ivanov C, Angelova I, Terziyska S, Paskov V. A new class of antiulcer drugs. I. Antiulcer effect of AN5, a 4-phenyl- tetrahydroisoquinoline derivative, on different experimental models of ulcer in rats. Methods Find Exp Clin Pharmacol. 1990 Jul-Aug;12(6):401-10. PMID: 2087139.
