Win 33377

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535718

CAS#: 146537-07-7

Description: Win 33377 is a bioactive chemical.

Chemical Structure

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Win 33377
CAS# 146537-07-7
Instruction

Theoretical Analysis

MedKoo Cat#: 535718
Name: Win 33377
CAS#: 146537-07-7
Chemical Formula: C21H27N3O3S2
Exact Mass: 433.15
Molecular Weight: 433.585
Elemental Analysis: C, 58.17; H, 6.28; N, 9.69; O, 11.07; S, 14.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Win 33377; Win33377; Win-33377

IUPAC/Chemical Name: Methanesulfonamide, N-((1-((2-(diethylamino)ethyl)amino)-9-oxo-9H-thioxanthen-4-yl)methyl)-

InChi Key: NAMOLZVVTPNNTE-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27N3O3S2/c1-4-24(5-2)13-12-22-17-11-10-15(14-23-29(3,26)27)21-19(17)20(25)16-8-6-7-9-18(16)28-21/h6-11,22-23H,4-5,12-14H2,1-3H3

SMILES Code: CS(=O)(NCC1=CC=C(NCCN(CC)CC)C(C2=O)=C1SC3=C2C=CC=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 433.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Izbicka E, Lawrence R, Davidson K, Rake JB, Von Hoff DD. Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells. Invest New Drugs. 1998-1999;16(3):221-5. doi: 10.1023/a:1006152100299. PMID: 10360601.


2: Drozd ML, Lockwood G, Miller B, Rosi D. A column-switching high-performance liquid chromatographic assay for a novel cytotoxic thioxanthone derivative (WIN 33377) in mouse plasma with toxicokinetic results from a mouse LD10 study. J Chromatogr B Biomed Appl. 1995 Aug 4;670(1):145-51. doi: 10.1016/0378-4347(95)00155-c. PMID: 7493072.


3: Cao LY, Huang H, Ni JH. [Progress in researches on drugs for prostate cancer]. Zhonghua Nan Ke Xue. 2003 Dec;9(9):703-6. Chinese. PMID: 14727365.


4: LoRusso PM, Foster BJ, Wozniak A, Heilbrun LK, McCormick JI, Ruble PE, Graham MA, Purvis J, Rake J, Drozd M, Lockwood GF, Corbett TH. Phase I pharmacokinetic study of the novel antitumor agent SR233377. Clin Cancer Res. 2000 Aug;6(8):3088-94. PMID: 10955788.


5: Stevenson JP, DeMaria D, Reilly D, Purvis JD, Graham MA, Lockwood G, Drozd M, O'Dwyer PJ. Phase I/pharmacokinetic trial of the novel thioxanthone SR233377 (WIN33377) on a 5-day schedule. Cancer Chemother Pharmacol. 1999;44(3):228-34. doi: 10.1007/s002800050971. PMID: 10453724.


6: Foster BJ, Wiegand RA, Pugh S, LoRusso PM, Rake J, Corbett TH. Pharmacokinetic studies in mice of two new thioxanthenones (183577 and 232759) that showed preferential solid tumor activity. Clin Cancer Res. 1997 Nov;3(11):2047-53. PMID: 9815596.