WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574796

CAS#: 193807-58-8

Description: JHN07588, also known as MMP-2/MMP-9 inhibitor I, is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9. It acts by binding zinc at the active site of these MMPs. This compound has been used to elucidate the roles of MMP-2 and MMP-9 in diverse systems, including mammary epithelial cell transformation, neuronal dysfunction, lymphocyte recruitment, and progressive hereditary kidney disease. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

CAS# 193807-58-8

Theoretical Analysis

MedKoo Cat#: 574796
Name: JHN07588
CAS#: 193807-58-8
Chemical Formula: C21H19NO4S
Exact Mass: 381.10
Molecular Weight: 381.446
Elemental Analysis: C, 66.12; H, 5.02; N, 3.67; O, 16.78; S, 8.40

Price and Availability

Size Price Availability Quantity
100mg USD 950 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2550 2 Weeks
1g USD 3850 2 Weeks
2g USD 6250 2 Weeks
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Related CAS #: 193807-58-8,

Synonym: MMP-2/MMP-9 inhibitor I; Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor I; JHN07588; JHN-07588; JHN 07588;

IUPAC/Chemical Name: N-([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine


InChi Code: InChI=1S/C21H19NO4S/c23-21(24)20(15-16-7-3-1-4-8-16)22-27(25,26)19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20,22H,15H2,(H,23,24)/t20-/m1/s1

SMILES Code: O=S(C(C=C1)=CC=C1C2=CC=CC=C2)(N[C@@H](C(O)=O)CC3=CC=CC=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Biological target: MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC50s of 0.24 and 0.31 μM for MMP-9 and MMP-2.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.0 65.54

Preparing Stock Solutions

The following data is based on the product molecular weight 381.446000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1. Tamura, Y., Watamane, F., Nakatani, T., et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J. Med. Chem. 41(4), 640-649 (1998). 2. Dechow, T.B., Pedranzini, L., Leitch, A., et al. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc. Natl. Acad. Sci. USA 101(29), 10602-10607 (2004). 3. Lim, K., Hyun, Y.-M., Lambert-Emo, K., et al. Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways. Science 349(6252), (2015). 4. Mizoguchi, H., Yamada, K., and Nabeshima, T. Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer’s disease, and epilepsy. 2011:681385, (2011). 5. Zeisberg, M., Khurana, M., Rao, V.H., et al. Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med. 3(4), (2006).