WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462968
Description: 2’-Deoxyinosine is the nucleoside form of hypoxanthine. It is a product of DNA damage that is formed from 2’-deoxyadenosine by adenosine deaminase or reactive nitrogen species. 2’-deoxyinosine enhances apoptosis induced by 5-fluorouracil in HT-29 and SW620 cancer cells. It also enhances 5-FU-induced tumor growth suppression in an SW620 mouse xenograft model when administered at a dose of 1.6 g/kg twice per day.
MedKoo Cat#: 462968
Chemical Formula: C10H12N4O4
Exact Mass: 252.0859
Molecular Weight: 252.23
Elemental Analysis: C, 47.62; H, 4.80; N, 22.21; O, 25.37
IUPAC/Chemical Name: 9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
InChi Key: VGONTNSXDCQUGY-RRKCRQDMSA-N
InChi Code: InChI=1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
SMILES Code: [H][C@@]1(N2C(N([H])C=NC3=O)=C3N=C2)O[C@H](CO)[C@@H](O)C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 252.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Shimo T , Tachibana K , Kawawaki Y , Watahiki Y , Ishigaki T , Nakatsuji Y , Hara T , Kawakami J , Obika S . Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides. Chem Commun (Camb). 2019 Jun 11;55(48):6850-6853. doi: 10.1039/c8cc09648a. PMID: 31123731.
2: Wang LJ, Luo ML, Yang XY, Li XF, Wu Y, Zhang CY. Controllable Autocatalytic Cleavage-Mediated Fluorescence Recovery for Homogeneous Sensing of Alkyladenine DNA Glycosylase from Human Cancer Cells. Theranostics. 2019 Jun 9;9(15):4450-4460. doi: 10.7150/thno.35393. PMID: 31285772; PMCID: PMC6599653.
3: Matyašovský J, Hocek M. 2-Substituted 2'-deoxyinosine 5'-triphosphates as substrates for polymerase synthesis of minor-groove-modified DNA and effects on restriction endonuclease cleavage. Org Biomol Chem. 2020 Jan 2;18(2):255-262. doi: 10.1039/c9ob02502b. PMID: 31815989.
4: Huang W, Liu C, Xie L, Wang Y, Xu Y, Li Y. Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide. Toxicol Res (Camb). 2019 Aug 7;8(6):850-861. doi: 10.1039/c9tx00067d. PMID: 32110379; PMCID: PMC7017871.