TPX-0022
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 408118

CAS#: 2271119-26-5

Description: TPX-0022, also known as CSF1R-IN-2, is an orally bioavailable multi-targeted kinase inhibitor with a novel three-dimensional macrocyclic structure that inhibits the MET, CSF1R (colony stimulating factor 1 receptor) and SRC kinases. Targeting CSF1R leads to the modulation of tumor-associated macrophages (TAMs), a type of immune cell that suppresses the T-cell mediated anti-tumor immune response. Inhibition of CSF1R with TPX-0022 is a promising therapeutic strategy as a single agent or in combination with standard of care chemotherapy and immunotherapy in various solid tumors.


Chemical Structure

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TPX-0022
CAS# 2271119-26-5

Theoretical Analysis

MedKoo Cat#: 408118
Name: TPX-0022
CAS#: 2271119-26-5
Chemical Formula: C20H20FN7O2
Exact Mass: 409.1663
Molecular Weight: 409.4254
Elemental Analysis: C, 58.67; H, 4.92; F, 4.64; N, 23.95; O, 7.82

Price and Availability

Size Price Availability Quantity
25.0mg USD 550.0 2 Weeks
50.0mg USD 950.0 2 Weeks
100.0mg USD 1650.0 2 Weeks
200.0mg USD 2650.0 2 Weeks
500.0mg USD 3650.0 2 Weeks
1.0g USD 5950.0 2 Weeks
2.0g USD 9950.0 2 Weeks
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Synonym: TPX-0022; TPX 0022; TPX0022; CSF1R-IN-2; Elzovantinib

IUPAC/Chemical Name: (S,13E,14E)-12-amino-2-ethyl-45-fluoro-6-methyl-9-oxo-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphane-46-carbonitrile

InChi Key: UUDPUQDMSHQSKH-NSHDSACASA-N

InChi Code: InChI=1S/C20H20FN7O2/c1-3-27-10-13-12(8-22)14(21)4-5-15(13)30-11(2)9-24-20(29)17-18(23)26-28-7-6-16(27)25-19(17)28/h4-7,11H,3,9-10H2,1-2H3,(H2,23,26)(H,24,29)/t11-/m0/s1

SMILES Code: N#CC1=C2CN(CC)C(C=C3)=NC(N3N=C4N)=C4C(NC[C@H](C)OC2=CC=C1F)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 409.4254 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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TPX-0022

25.0mg / USD 550.0