KF-38789
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574764

CAS#: 257292-29-8

Description: KF-38789 is a selective inhibitor of P-selectin-mediated cell adhesion that blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.

Chemical Structure

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KF-38789
CAS# 257292-29-8
Instruction

Theoretical Analysis

MedKoo Cat#: 574764
Name: KF-38789
CAS#: 257292-29-8
Chemical Formula: C19H21NO5S
Exact Mass: 375.11
Molecular Weight: 375.440
Elemental Analysis: C, 60.78; H, 5.64; N, 3.73; O, 21.31; S, 8.54

Price and Availability

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10mg USD 550 2 Weeks
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Synonym: KF-38789, KF38789, KF 38789

IUPAC/Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one

InChi Key: NHFIAAAMCYVRIW-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21NO5S/c1-11-8-15(21)18(19(22)25-11)14-10-17(26-7-6-20-14)13-5-4-12(23-2)9-16(13)24-3/h4-5,8-9,17,21H,6-7,10H2,1-3H3

SMILES Code: O=C1C(C2=NCCSC(C3=CC=C(OC)C=C3OC)C2)=C(O)C=C(C)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 375.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275 PMID: 10780927

2. Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544 PMID: 11766994

3. Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21 PMID: 17201408