Kanosamine HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574761

CAS#: 57649-10-2

Description: Kanosamine is an antibiotic that inhibits cell wall synthesis in plant-pathogenic oomycetes, certain fungi, and some bacterial species. It has been explored as an alternative and/or supplement to synthetic pesticides and genetic resistance of crop plants for the management of plant disease.

Chemical Structure

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Kanosamine HCl
CAS# 57649-10-2
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 574761
Name: Kanosamine HCl
CAS#: 57649-10-2
Chemical Formula: C6H14ClNO5
Exact Mass: 215.06
Molecular Weight: 215.630
Elemental Analysis: C, 33.42; H, 6.54; Cl, 16.44; N, 6.50; O, 37.10

Price and Availability

Size Price Availability Quantity
5mg USD 450 2 Weeks
10mg USD 800 2 Weeks
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Synonym: Kanosamine HCl

IUPAC/Chemical Name: 3-amino-3-deoxy-D-glucose, monohydrochloride

InChi Key: ADFOMBKCPIMCOO-BTVCFUMJSA-N

InChi Code: InChI=1S/C6H13NO5.ClH/c7-5(3(10)1-8)6(12)4(11)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6+;/m0./s1

SMILES Code: O=C([H])[C@H](O)[C@@H](N)[C@H](O)[C@H](O)CO.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few Bacterial species.
In vitro activity: Kanosamine was highly inhibitory to growth of plant-pathogenic oomycetes and moderately inhibitory to certain fungi and inhibited few bacterial species tested. Reference: Appl Environ Microbiol. 1996 Aug;62(8):3061-5. https://pubmed.ncbi.nlm.nih.gov/8702302/
In vivo activity: Kanosamine was highly inhibitory to growth of plant-pathogenic oomycetes and moderately inhibitory to certain fungi and inhibited few bacterial species tested. Reference: Appl Environ Microbiol. 1996 Aug;62(8):3061-5. https://pubmed.ncbi.nlm.nih.gov/8702302/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 25.0 115.94
DMSO 25.0 115.94
Ethanol 5.0 23.19
PBS (pH 7.2) 10.0 46.38

Preparing Stock Solutions

The following data is based on the product molecular weight 215.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Milner JL, Silo-Suh L, Lee JC, He H, Clardy J, Handelsman J. Production of kanosamine by Bacillus cereus UW85. Appl Environ Microbiol. 1996 Aug;62(8):3061-5. doi: 10.1128/aem.62.8.3061-3065.1996. PMID: 8702302; PMCID: PMC168096.
In vitro protocol: 1. Milner JL, Silo-Suh L, Lee JC, He H, Clardy J, Handelsman J. Production of kanosamine by Bacillus cereus UW85. Appl Environ Microbiol. 1996 Aug;62(8):3061-5. doi: 10.1128/aem.62.8.3061-3065.1996. PMID: 8702302; PMCID: PMC168096.
In vivo protocol: 1. Milner JL, Silo-Suh L, Lee JC, He H, Clardy J, Handelsman J. Production of kanosamine by Bacillus cereus UW85. Appl Environ Microbiol. 1996 Aug;62(8):3061-5. doi: 10.1128/aem.62.8.3061-3065.1996. PMID: 8702302; PMCID: PMC168096.

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1. Milner, J.L., Silo-Suh, L., Lee, J.C., et al. Production of kanosamine by Bacillus cereus UW85. Appl. Environ. Microbiol. 62(8), 3061-3065 (1996).

2. Dolak, L.A., Castle, T.M., Dietz, A., et al. 3-Amino-3-deoxyglucose produced by a Streptomyces sp. J.Antibiot.(Tokyo) 33(8), 900-901 (1980).