WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574760
CAS#: 944342-90-9
Description: JNJ-28871063 hydrochloride is an ErbB receptor family inhibitor that inhibits growth of human cancer cell lines overexpressing ErbB2 and growth of human tumor xenografts.
MedKoo Cat#: 574760
Name: JNJ-28871063 hydrochloride
CAS#: 944342-90-9
Chemical Formula: C24H28Cl2N6O3
Exact Mass: 518.16
Molecular Weight: 519.43
Elemental Analysis: C, 55.50; H, 5.43; Cl, 13.65; N, 16.18; O, 9.24
Synonym: JNJ-28871063 hydrochloride; JNJ-28871063 HCl
IUPAC/Chemical Name: (E)-4-amino-6-((4-(benzyloxy)-3-chlorophenyl)amino)pyrimidine-5-carbaldehyde O-(2-morpholinoethyl) oxime hydrochloride
InChi Key: ZXKZRKQMKNRZNN-GZPZNDDGSA-N
InChi Code: InChI=1S/C24H27ClN6O3.ClH/c25-21-14-19(6-7-22(21)33-16-18-4-2-1-3-5-18)30-24-20(23(26)27-17-28-24)15-29-34-13-10-31-8-11-32-12-9-31;/h1-7,14-15,17H,8-13,16H2,(H3,26,27,28,30);1H/b29-15+;
SMILES Code: ClC1=CC(NC2=C(/C=N/OCCN3CCOCC3)C(N)=NC=N2)=CC=C1OCC4=CC=CC=C4.[H]Cl
Appearance: Solid powder
Purity: >97% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 519.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Contessa and Hamstra (2008) Revoking the privilege: targeting HER2 in the central nervous system. Mol.Pharmacol. 73 271 PMID: 17981994
2. Emanuel et al (2008) Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors. Mol.Pharmacol. 73 338 PMID: 17975007
3. Guessous et al (2008) Signaling pathways in medulloblastoma. J.Cell.Phys. 217 577
